The role of long non-coding RNA AFAP1-AS1 in human malignant tumors

Pathology, Research and Practice
Daolin JiYunfu Cui

Abstract

Long non-coding RNAs (lncRNAs) are a type Table of endogenous RNA longer than 200 nucleotides in length, and this kind of RNAs lack or possess limited ability of coding proteins. A large number of studies have demonstrated that lncRNAs could take part in massive biological processes, such as transcriptional activation and interference, cellular differentiation, proliferation, migration, invasion and apoptosis. The abnormal expression of lncRNAs has been clarified to play extremely important roles in various diseases, especially in human cancers. LncRNA actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) is a newly recognized cancer-related lncRNA deriving from the antisense strand of DNA at the AFAP1 coding gene locus. A slew of new studies suggest that AFAP1-AS1 is involved in many kinds of malignant tumors. Moreover, in recent years, the dysregulated expression of AFAP1-AS1 has been confirmed to be associated with oncogenesis and tumor progression. Evidence has increasingly shown that AFAP1-AS1 could probably serve as a novel potential molecular biomarker in tumor diagnosis and therapeutic target in tumor treatment. In this review, we sum up present stage new hottest research issues in respect of the biological fu...Continue Reading

Citations

Nov 14, 2019·Genes·Berta Luzón-ToroSalud Borrego
Jun 18, 2020·Journal of Cellular and Molecular Medicine·Qi ZhangYing Lin
Nov 22, 2018·Cancer Cell International·Xu BinTang Binbin
Jun 30, 2019·International Journal of Molecular Sciences·Xuda MaYongmei Li
Sep 20, 2020·Cancer Letters·Jun CaoMeiyu Fang
Jul 27, 2021·Experimental and Therapeutic Medicine·Wen-Bin LiuFu-Jiang Zhang
Jun 17, 2019·Pathology, Research and Practice·Ming Yang, Wenbin Wei
Jan 4, 2022·Breast Cancer Research and Treatment·Jazib GoharLauren E McCullough

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