PMID: 9171840Apr 1, 1997Paper

The role of low level Plasmodium falciparum parasitaemia in anaemia among infants living in an area of intense and perennial transmission

Tropical Medicine & International Health : TM & IH
A KituaM Tanner

Abstract

Children under one year of age in an area of intense and perennial Plasmodium falciparum transmission were followed up for one year to establish to what extent chronic, low parasitaemia was associated with severe anaemia. There was a significant increase in the prevalence of anaemia (PCV < or = 25%) with increase in parasite density. PCV levels were related not only to concurrent parasite density but also decreased with densities measured one month previously. At any point in time, the mean PCV level in infants with low parasitaemia (< 1000 parasites/microliter) was higher than that of infants with intermediate (1000-9999/microliter) and high parasite densities (> or 10000/microliter). After the age of 7 months, infants with low parasite densities tend to recover, probably as a result of developing immunity. At the age of 12 months, they have similar PCV levels to infants with no detectable parasitaemia by microscopy. The maintenance of low parasite density appears crucial to the survival of infants in malaria endemic areas. The findings suggest that interventions which lower parasite densities in areas of intense transmission reduce the development of severe malarial anaemia and thus malaria-related mortality and morbidity in ...Continue Reading

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Citations

Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SmithH P Beck
Jan 10, 2006·Tropical Medicine & International Health : TM & IH·R IdroG W Kivumbi
Apr 21, 2007·Tropical Medicine & International Health : TM & IH·Patrick van RheenenBernard Brabin
May 13, 1999·Tropical Medicine & International Health : TM & IH·F P MockenhauptU Bienzle
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SmithH P Beck
Apr 15, 1999·Tropical Medicine & International Health : TM & IH·H P Beck
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robin KobbeJürgen May
Dec 10, 2008·The New England Journal of Medicine·Harin A KarunajeewaTimothy M E Davis
Jun 6, 2012·The American Journal of Tropical Medicine and Hygiene·Thomas JaenischDavid J Sullivan
Mar 26, 2015·PloS One·Manas KotepuiSuwit Duangmano
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·M TannerT Smith
Aug 24, 2006·Annals of Tropical Paediatrics·Patrick F van RheenenBernard J Brabin
Jan 9, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B A IwalokunA Ogunledun
Mar 3, 2017·Infectious Diseases of Poverty·Manas KotepuiKwuntida Uthaisar
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SmithM Tanner
Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·J MayC G Meyer
Apr 21, 2017·PloS One·Evans RaballahJohn Michael Ong'echa
Mar 6, 2021·Malaria Journal·Syilvia Jiero, Ayodhia Pitaloka Pasaribu
Oct 31, 2009·Acta Tropica·Akintunde SowunmiBabasola A Fateye

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