PMID: 8582960Jul 1, 1995Paper

The role of luteinizing hormone in human follicle development and oocyte fertility: evidence from in-vitro fertilization in a woman with long-standing hypogonadotrophic hypogonadism and using recombinant human follicle stimulating hormone

Human Reproduction
J BalaschJ A Vanrell

Abstract

To evaluate the relative importance of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in follicular development and oocyte fertility in the human species, the use of recombinant human FSH, human menopausal gonadotrophin (HMG), and very highly purified urinary human FSH (FSH-HP) plus oestradiol valerate for ovarian stimulation and in-vitro fertilization (IVF) were compared in three cycles in a woman with isolated congenital gonadotrophin deficiency who had never been treated with ovarian stimulating agents. The total number of ampoules of gonadotrophins used was lower in the HMG treatment cycle. Ovarian response and IVF outcome in the three treatment cycles were as follows: (i) HMG cycle: normal follicular growth, normal pattern of oestradiol and inhibin through the menstrual cycle, high fertilization rate (93%); (ii) recombinant FSH cycle: normal follicular growth, low oestradiol and abnormal inhibin, finally poor rate of fertilization (28%); (iii) FSH-HP plus oestradiol valerate cycle: normal follicular growth, normal pattern of inhibin and poor fertilization rate (27%). Luteal plasma progesterone concentrations were much higher in the HMG treatment cycle. This case shows that FSH is the only factor required i...Continue Reading

Citations

Jun 16, 2001·Endocrine Reviews·S F PalterE Y Adashi
Jan 30, 2019·Human Fertility : Journal of the British Fertility Society·Isıl KasapogluGürkan Uncu
May 29, 2002·Current Opinion in Obstetrics & Gynecology·Juan Balasch, Francisco Fábregues
Jun 17, 2003·Clinical Obstetrics and Gynecology·Howard D McClamrock
Feb 9, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F LisiM Moscarini
Jan 29, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisco FábreguesJuan Balasch
Oct 19, 2019·Journal of Assisted Reproduction and Genetics·Gustavo N CecchinoJuan A García-Velasco
Apr 11, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Kamel Abdelhakim MohamedHany Lashen
Apr 9, 2005·Journal of Endocrinological Investigation·N AngelopoulosG Tolis
Jan 8, 2021·Journal of Assisted Reproduction and Genetics·John S RushingCassandra Roeca
Jul 17, 1998·Frontiers in Neuroendocrinology·N Chabbert BuffetP Bouchard
Feb 27, 2007·Theriogenology·Pascal SalvettiThierry Joly
Jun 23, 2005·Reproductive Biomedicine Online·Gamze Sinem CaglarSafaa Al-Hasani

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