The role of lymphatic mapping and sentinel lymph node biopsy in the staging and treatment of melanoma

Clinics in Plastic Surgery
Wayne K Stadelmann

Abstract

The incidence of malignant melanoma is increasing at an alarming rate, doubling in women and growing by more 300% in men during the past 25 years. The importance of diagnosing nodal metastatic disease, with the ability to detect smaller and smaller volumes of tumor in the sentinel lymph nodes (SLNs) biopsied using immunohistochemical staining, has impacted the accurate staging and stratification of melanoma patients. The role that elective lymph node dissection now plays in staging the melanoma patient and determining subsequent treatment has been greatly diminished in favor of less morbid and less invasive techniques that have a higher degree of accuracy in detecting occult nodal disease. This article explores what has driven the advent of selective or SLN biopsy, the rationale behind obtaining a preoperative lymphoscintigram, the technical details of the SLN biopsy procedure, and the refinement in the pathologic detection of ever smaller volumes of tumor in nymph node tissue removed. The role that these new modalities have played in changing the dynamic field of melanoma care is emphasized.

References

Jan 1, 1992·Annals of Plastic Surgery·A Trotti, L J Peters
Apr 1, 1992·Archives of Surgery·D L MortonA J Cochran
Jan 1, 1992·Annals of Plastic Surgery·C G BermanR A Clark
Apr 1, 1991·Archives of Surgery·U Veronesi, N Cascinelli
Jan 1, 1985·British Journal of Plastic Surgery·M E McKeanI A McGregor
May 1, 1969·Radiology·W HauserP Richards
Jun 1, 1995·Archives of Surgery·D N KragJ C Alex
Dec 1, 1994·The British Journal of Surgery·H van der VeenS Meijer
Nov 1, 1994·American Journal of Surgery·C J O'BrienV Malka
Dec 1, 1994·Annals of Surgery·D ReintgenG Lyman
Apr 1, 1994·Plastic and Reconstructive Surgery·K E WellsD S Reintgen
Oct 1, 1993·Surgical Oncology·J C AlexD N Krag
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M KirkwoodR H Blum
Jul 1, 1997·The Journal of Hand Surgery·W K StadelmannD S Reintgen
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E GershenwaldM I Ross
Jun 26, 1998·Annals of Surgical Oncology·K M HeatonM I Ross
Oct 6, 1998·Hematology/oncology Clinics of North America·W K Stadelmann, D S Reintgen
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E GershenwaldM I Ross
Jul 14, 1999·Annals of Plastic Surgery·K E WellsD Reintgen
Sep 3, 1999·Journal of the American College of Surgeons·P R KelemenD L Morton
Jun 6, 2000·Plastic and Reconstructive Surgery·W K StadelmannD S Reintgen
Apr 21, 2001·Annals of Surgical Oncology·K M McMastersM J Edwards
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M McMastersD G Coit
Jun 8, 2001·Current Oncology Reports·L M Schuchter
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchA Morabito
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Oct 13, 2001·Annals of Surgical Oncology·H Medina-FrancoM M Urist
Jan 5, 2002·Annals of Surgical Oncology·S DessureaultUNKNOWN American Joint Committee on Cancer (AJCC) Melanoma Staging Committee
May 2, 2002·Archives of Surgery·Kelly M McMastersUNKNOWN Sunbelt Melanoma Trial Group
Jul 30, 2002·Anesthesia and Analgesia·Leslie L MontgomeryPatrick I Borgen
Dec 19, 2002·American Journal of Surgery·Celia ChaoUNKNOWN Sunbelt Melanoma Trial Group

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Citations

Aug 30, 2013·Plastic and Reconstructive Surgery·William W Dzwierzynski
Mar 12, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Oliver C ThieleKolja Freier
May 18, 2010·Expert Review of Anticancer Therapy·Richard Essner
Dec 21, 2010·Expert Review of Anticancer Therapy·Valerio MaisGian Benedetto Melis
Nov 5, 2010·Current Opinion in Supportive and Palliative Care

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