The role of lymphatic transport in enhancing oral protein and peptide drug delivery

Drug Development and Industrial Pharmacy
Kishor M Wasan

Abstract

The gastrointestinal lymphatic system is a specific transport pathway through which dietary lipids, fat-soluble vitamins, and water-insoluble peptide-type molecules (e.g., cyclosporine A) can gain access to the systemic circulation. Drugs transported by way of the gastrointestinal lymphatic system bypass the liver and avoid potential hepatic first-pass metabolism. Lymphatic delivery of immunomodulatory and low therapeutic index protein and peptide drugs used in the treatment of cancer cell metastases and HIV presents an opportunity to maximize therapeutic benefit while minimizing general systemic drug exposure. Furthermore, lymphatic drug transport may promote drug incorporation into the body's lipid-handling system, thus offering the potential to manipulate drug distribution and residence time within the body. This review article will discuss the potential utilization of lymphatic transport in enhancing the oral absorption of protein- and peptide-like drugs.

References

Jul 1, 1992·The Journal of Pharmacy and Pharmacology·T IchihashiH Yamada
Jul 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T IchihashiH Yamada
Jul 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T IchihashiH Yamada
Jul 1, 1991·Journal of Pharmaceutical Sciences·P C SheenA T Serajuddin
Mar 1, 1989·Canadian Journal of Physiology and Pharmacology·A B ThomsonM T Clandinin
Apr 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·G B McDonald, M Weidman
Oct 1, 1988·Pharmaceutical Research·J P ReymondJ Vonderscher
May 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·D L BusbeeC O Joe
Aug 1, 1972·The Australian Journal of Experimental Biology and Medical Science·W J Simmonds
Oct 1, 1965·The Journal of Clinical Investigation·D B Zilversmit
Sep 1, 1984·The Journal of Pharmacy and Pharmacology·K J Palin, C G Wilson
Jan 1, 1981·The American Journal of Physiology·E W Stephenson
Jan 1, 1983·Annual Review of Physiology·M C CareyC M Bliss
Apr 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R C Grimus, I Schuster
Nov 1, 1994·Biological & Pharmaceutical Bulletin·H SatoI Horikoshi
May 22, 1993·Lancet·G Tucker
Aug 1, 1993·Canadian Journal of Physiology and Pharmacology·A B ThomsonM T Clandinin
Mar 1, 1993·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·I AdachiH Sato
May 1, 1996·Journal of Pharmaceutical Sciences·A J HumberstoneW N Charman
Sep 1, 1996·Pharmaceutical Research·U FagerholmH Lennernäs
Jul 1, 1997·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·S Muranishi
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M V PahlN D Vaziri
Oct 1, 1957·The Journal of Clinical Investigation·B BORGSTROMJ SJOVALL
Dec 6, 1957·Science·E J REININGER, L A SAPIRSTEIN
Aug 1, 1960·The Journal of Clinical Investigation·L HELLMANR S ROSENFELD
Nov 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·M W BIGGSS O BYERS

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Citations

Sep 6, 2012·Therapeutic Delivery·Marshall Grant, Andrea Leone-Bay
Jun 15, 2005·Expert Opinion on Biological Therapy·Corina BorghoutsBernd Groner
Oct 20, 2004·Drug Development and Industrial Pharmacy·Verica RisovicKishor M Wasan
Oct 23, 2003·Drug Development and Industrial Pharmacy·Ramaswamy Subramanian, Kishor M Wasan
Nov 5, 2010·Advanced Drug Delivery Reviews·Stephen R DuekerJohn S Vogel
Jul 6, 2010·Peptides·Bahareh H Sarmadi, Amin Ismail
May 10, 2011·Journal of Clinical Pharmacology·Werner SiegmundWilhelm Kirch
Sep 6, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Pavel Gershkovich, Amnon Hoffman
Jun 21, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ching-Jou Lim, Wei-Chiang Shen
Apr 16, 2016·Journal of Proteomics·Elena MaestriNelson Marmiroli
Sep 27, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jeffrey D Miller
Jul 23, 2013·International Journal of Pharmaceutics·T T H PhamG Barratt
Feb 20, 2019·CPT: Pharmacometrics & Systems Pharmacology·Felix StaderCatia Marzolini

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