The role of lymphoscintigraphy in the detection of lymph node drainage in melanoma

Surgical Oncology Clinics of North America
Roger F UrenDavid Chung

Abstract

Lymphatic drainage of the skin cannot be predicted based on clinical guidelines developed more than 100 years ago. Approximately 30% of patients experience drainage from the skin to unexpected lymph node sites rather than those specified by these guidelines, and therefore these outdated assumptions should no longer be used to plan surgery. A possible survival benefit has been shown for the early detection and surgical removal of metastatic disease in the draining lymph nodes, and therefore, clinicians must obtain accurate lymphatic mapping for each patient who has intermediate thickness melanoma to plan appropriate surgical therapy. Lymphoscintigraphy can be used to accurately define the precise position of each true sentinel node in every patient, whether these nodes lie in a standard node field or in an unusual location. In this way, lymphoscintigraphy has a direct beneficial impact on the surgical management of patients who have melanoma.

References

Apr 1, 1992·Archives of Surgery·D L MortonA J Cochran
Jan 1, 1989·Annals of Plastic Surgery·M A Eberbach, R L Wahl
Oct 1, 1981·AJR. American Journal of Roentgenology·D C SullivanH F Seigler
May 1, 1996·Clinical Nuclear Medicine·R F UrenM J Quinn
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J F ThompsonR F Uren
Nov 5, 1997·Health Physics·J R RussellE Watson
Jul 6, 2000·British Journal of Plastic Surgery·G A O'TooleB W Powell
Apr 5, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Markwin G Statius MullerSybren Meijer
May 2, 2002·Archives of Surgery·Kelly M McMastersUNKNOWN Sunbelt Melanoma Trial Group
Jan 20, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L KretschmerH Starz
Jun 1, 2005·Plastic and Reconstructive Surgery·Hiroo SuamiWei-Ren Pan

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Citations

Mar 17, 2007·International Journal of Health Geographics·Jane L GarbRichard B Wait
Aug 29, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Annette H ChakeraUNKNOWN European Association of Nuclear Medicine-European Organisation for Research and
Mar 19, 2011·Expert Opinion on Drug Delivery·Gregory Russell-Jones, Roy Himes
Oct 4, 2007·Medical Hypotheses·Feng YangQuan Xing Ni
May 21, 2009·Veterinary and Comparative Oncology·J L TuohyW S Dernell
Feb 18, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·M Lens
Dec 18, 2007·Seminars in Oncology·Mark B Faries, Donald L Morton
Jan 8, 2015·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Timothy L FitzgeraldJan H Wong
Sep 20, 2007·Journal of Surgical Oncology·Christine S LandryCharles R Scoggins
Jan 11, 2012·Aesthetic Surgery Journal·Ricardo A MeadeFritz E Barton
Jun 3, 2020·Surgical Oncology Clinics of North America·Jessica Crystal, Mark B Faries
Feb 28, 2008·Current Opinion in Oncology
Oct 16, 2021·Clinical & Experimental Metastasis·Stanley P LeongAmanda W Lund

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