The role of macrophages in utero-placental interactions during normal and pathological pregnancy

Immunological Investigations
Stephen J Renaud, Charles H Graham

Abstract

The intimate association between maternal and placental tissues elicits an interesting immunological paradox. Placental tissue contains paternal antigens, but under normal circumstances the semi-allogeneic fetus and placenta are not attacked by the maternal immune system. Interestingly, this tolerance to fetal antigens occurs in the presence of a large number of maternal leukocytes, almost all of which are members of the innate immune system. Macrophages are one of the most abundant leukocytes in the decidua and their numbers remain constant throughout gestation. They are recruited to the decidua by both stromal cells and trophoblast cells, where they adopt a specialized phenotype that may assist in various aspects of decidual homeostasis, placental development, and tolerance to the semi-allogeneic trophoblast. Aberrant behavior of these macrophages can affect trophoblast function and placental development, potentially leading to a spectrum of adverse pregnancy outcomes ranging from pre-eclampsia to fetal growth restriction or demise. This review will focus on the phenotype and putative functions of decidual macrophages in normal pregnancy, and how abnormal activation of these cells can affect various aspects of placental devel...Continue Reading

References

Apr 1, 1977·British Journal of Obstetrics and Gynaecology·C M TowlerI MacGillivray
Jul 1, 1992·Immunology Today·A MantovaniL Ruco
Oct 1, 1992·American Journal of Obstetrics and Gynecology·K D HeyborneJ A McGregor
Aug 1, 1991·Journal of Cellular Physiology·C H Graham, P K Lala
Apr 1, 1991·Australian and New Zealand Journal of Medicine·M A Brown
Sep 1, 1989·Journal of Reproductive Immunology·J S Hunt
Aug 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·J R Oksenberg, C Brautbar
Jun 1, 1988·Journal of Medical Microbiology·A M O'SullivanA P Johnson
Apr 1, 1987·The Journal of Clinical Investigation·R W Redline, C Y Lu
Mar 1, 1988·The American Journal of the Medical Sciences·J M Dicke, G I Henderson
Feb 15, 1981·American Journal of Obstetrics and Gynecology·B R CarrJ C Porter
Mar 1, 1994·Journal of Leukocyte Biology·C SunderkötterC Sorg
Jul 1, 1994·American Journal of Obstetrics and Gynecology·M M FaasW W Bakker
Nov 1, 1993·Journal of Reproduction and Fertility·A M SharkeyS K Smith
May 1, 1994·American Journal of Obstetrics and Gynecology·G T ColbernE K Main
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R L Kendall, K A Thomas
Jan 1, 1993·Developmental Medicine and Child Neurology·M Adinolfi
Jan 1, 1996·Life Sciences·L Miller, J S Hunt
Aug 1, 1996·The Journal of Experimental Medicine·I RothS J Fisher
Nov 5, 1997·American Journal of Reproductive Immunology : AJRI·J Szekeres-BarthoI Achatz
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Rouas-FreissE D Carosella
Nov 14, 1997·Immunology Today·R Raghupathy
Dec 6, 1997·Nature·R E VollI Girkontaite
Jan 10, 1998·American Journal of Obstetrics and Gynecology·S C SmithE M Symonds
Feb 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R WilsonJ J Walker
Feb 20, 1998·Journal of Leukocyte Biology·Y Y WangG W Wood
Feb 24, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D L RiveraM J Miller

❮ Previous
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Citations

Sep 10, 2010·Infectious Diseases in Obstetrics and Gynecology·Jessica E ThaxtonSurendra Sharma
Oct 3, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·I GranotN Dekel
Jan 10, 2013·Annual Review of Immunology·Adrian Erlebacher
Jan 12, 2016·American Journal of Reproductive Immunology : AJRI·Fen NingGendie E Lash
Dec 22, 2015·Biochemical and Biophysical Research Communications·Xiaomin KangAimin Zhao
Jun 7, 2011·Journal of Reproductive Immunology·Cheuk-Lun LeePhilip C N Chiu
Jul 4, 2012·Developmental Neurobiology·Elaine Y Hsiao, Paul H Patterson
Mar 6, 2012·American Journal of Reproductive Immunology : AJRI·Sun Young KimJung-Sun Kim
Dec 5, 2012·Journal of Cellular and Molecular Medicine·Oksana ShynlovaStephen J Lye
Mar 18, 2011·American Journal of Reproductive Immunology : AJRI·Safinur AtayDouglas D Taylor
Oct 9, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Vanessa ToppingJung-Sun Kim
Nov 11, 2011·American Journal of Obstetrics and Gynecology·Subhabrata BasuSylvie Hauguel-de Mouzon
Mar 4, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Genevieve EastabrookIan Sargent
May 19, 2011·International Immunopharmacology·Ziyan YangXia Zhang
Aug 21, 2013·Journal of Reproductive Immunology·Michael KoldehoffAhmet H Elmaagacli
Jul 30, 2014·Frontiers in Immunology·Marijke M FaasPaul De Vos
Jun 12, 2016·Seminars in Immunopathology·Mayumi MoriJúlia Szekeres-Bartho
Apr 2, 2010·Journal of Reproductive Immunology·Ayesha ShakhawatNelson Fernández
Oct 27, 2016·Placenta·R J BuckleyJ E Cartwright
Jan 2, 2018·Journal of Oral Microbiology·Leticia ReyesMary Brown
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens
Dec 23, 2008·Expert Review of Molecular Diagnostics·Ming-Huei Cheng, Peng-Hui Wang
Jul 10, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Manoj K JenaNihar R Nayak
Jan 31, 2020·The Tohoku Journal of Experimental Medicine·Jun KitazawaTakashi Murakami
Apr 8, 2014·Journal of Perinatal Medicine·Yen-Chang Lee, Syh-Jae Lin
Jun 5, 2016·Bulletin of Experimental Biology and Medicine·T Yu LvovaD I Sokolov
Aug 26, 2020·HLA : Immune Response Genetics·Michael EikmansSebastiaan Heidt
Aug 25, 2016·American Journal of Reproductive Immunology : AJRI·Yerbol BekmukhambetovMaral Bekzhanova
Jul 26, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Betul DundarGulten Ozgen
Sep 6, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judit SvenssonJan Ernerudh
Nov 14, 2019·International Journal of Molecular Sciences·Carlo TicconiAsgerally Fazleabas

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