The Role of Magnetoencephalography in the Early Stages of Alzheimer's Disease

Frontiers in Neuroscience
David López-SanzFernando Maestu

Abstract

The ever increasing proportion of aged people in modern societies is leading to a substantial increase in the number of people affected by dementia, and Alzheimer's Disease (AD) in particular, which is the most common cause for dementia. Throughout the course of the last decades several different compounds have been tested to stop or slow disease progression with limited success, which is giving rise to a strong interest toward the early stages of the disease. Alzheimer's disease has an extended an insidious preclinical stage in which brain pathology accumulates slowly until clinical symptoms are observable in prodromal stages and in dementia. For this reason, the scientific community is focusing into investigating early signs of AD which could lead to the development of validated biomarkers. While some CSF and PET biomarkers have already been introduced in the clinical practice, the use of non-invasive measures of brain function as early biomarkers is still under investigation. However, the electrophysiological mechanisms and the early functional alterations underlying preclinical Alzheimer's Disease is still scarcely studied. This work aims to briefly review the most relevant findings in the field of electrophysiological brai...Continue Reading

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Citations

Aug 23, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Laura E HughesUNKNOWN BioFIND Working Group
Sep 19, 2020·International Journal of Molecular Sciences·Mar PérezJesús Avila
Oct 24, 2018·Frontiers in Medicine·David López-SanzStefan Walter
Jun 12, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Emine Elif TülayTamer Demiralp
Nov 28, 2020·Neuroscience·Jesús Avila, George Perry
Feb 26, 2021·Computational Intelligence and Neuroscience·Yulong FengHong Guo

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Software Mentioned

Gephi
Matlab
Fieldtrip
Google Scholar
MNE Python
Brain Connectivity Toolbox
EEGLAB
BrainNet Viewer
HERMES
Brainstorm

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