The role of mannose receptor on HIV-1 entry into human spermatozoa

American Journal of Reproductive Immunology : AJRI
Walter Cardona-MayaAngela Cadavid

Abstract

In this opinion article we consider the possibility that human spermatozoa have receptors for human immunodeficiency virus-1 (HIV-1). It is clear that sperm cells have the potential for transmitting HIV-1, but the mechanisms responsible for spreading or the virus by this vector are not known. In contrast to the traditional HIV-1 target cells, spermatozoa do not express CD4 receptors or the CCR5/CXCR4 co-receptors. Recent evidence indicates that astrocytes, which also do not express these molecules, can be infected with HIV-1 through the mannose receptor. Furthermore, a 160-kDa sperm receptor that interacts with the HIV gp 120 has been described. Therefore, we hypothesize that the mannose receptor, of 165-175 kDa, is the receptor that HIV-1 uses to invade spermatozoa, which could lead to both vertical and horizontal transmission of HIV-1.

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Citations

Oct 28, 2009·The Journal of Experimental Medicine·Ana CeballosJorge Geffner
Oct 22, 2011·Journal of Reproductive Immunology·Walter Cardona-MayaMaría T Rugeles
Jun 1, 2016·Journal of Assisted Reproduction and Genetics·Walter D Cardona MayaPaula A Velilla
Sep 21, 2007·Carbohydrate Research·Zhao-Jun YinZhong-Jun Li
Dec 21, 2018·Andrologia·Weihua LiuDaishu Han
Dec 17, 2009·AIDS·Deborah J AndersonKenneth H Mayer
Oct 22, 2014·Nature Reviews. Urology·Fabrícia GimenesMarcia E L Consolaro
Mar 14, 2009·Microscopy Research and Technique·Jean-Pierre Dadoune
Oct 2, 2020·Journal of Virology·Dominique MahéNathalie Dejucq-Rainsford
May 23, 2021·Developmental and Comparative Immunology·Zhiwei Liao, Jianguo Su

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