PMID: 7538495Mar 1, 1995Paper

The role of mast cells in treatment of scabies

International Journal of Dermatology
M AmerM el-Harras

Abstract

The purpose of this study was to recognize the role of mast cells in the pathogenesis of scabies. One hundred and fifty patients and 10 controls were included in the study. Group 1 included 20 patients without previous treatment. In group 2, 80 patients were treated with antiscabietic drugs. Group 3 had 50 patients who received an antiscabietic drug followed by 3 days of crotamiton. Diurnal and nocturnal skin biopsies were taken from group 1. In groups 2 and 3, the biopsies were taken after 2 weeks of treatment. Sections were cut and stained by hematoxylin and eosin and Giemsa stains. Mast cells were increased in diurnal and nocturnal biopsies. Evident degranulation of mast cells was detected in nocturnal biopsies. The mast cell number decreased to half its pretreatment number in patients treated with antiscabietic drugs and to its normal number in patients treated with antiscabietic drugs followed by 3 days with crotamiton. The number of mast cells are increased in scabietic lesions. This plays a role in the pathogenesis of the clinical and histologic picture of scabies. We recommend that an antiscabietic drug should be followed by 3 days of crotamiton in the treatment of scabies.

References

Oct 1, 1979·Journal of the American Academy of Dermatology·W E Martin, C E Wheeler
Jan 1, 1988·International Journal of Dermatology·D J Van Neste
Dec 1, 1974·The Journal of Investigative Dermatology·B W Hancock, A M Ward
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Jan 1, 1980·The British Journal of Dermatology·E S Falk
Oct 1, 1980·The British Journal of Dermatology·E S Falk, R Bolle

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Citations

Aug 27, 2009·Pediatric Dermatology·Alice PhanLuc Thomas
Aug 20, 2009·Pediatric Dermatology·Inés García SalcesMilagros Sanchez
Apr 29, 2008·Bulletin of the World Health Organization·Danielle B ClucasRoss M Andrews
Jul 28, 2005·Clinical and Experimental Dermatology·C Mauleón-FernandezR Ruiz-Maldonado
Oct 18, 2002·Pediatric Dermatology·Kyoung-Jin KimJai-Kyoung Koh
Aug 12, 2017·Parasites & Vectors·Sajad A BhatShelley F Walton
Feb 7, 2013·Current Opinion in Infectious Diseases·Shelley F Walton, Florin I Oprescu
May 8, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·H S KimG Yosipovitch

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