The role of maternal obesity in infant outcomes in polycystic ovary syndrome-A systematic review, meta-analysis, and meta-regression

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
Mahnaz Bahri KhomamiLisa J Moran

Abstract

Polycystic ovary syndrome (PCOS) is associated with worsened pregnancy and infant outcomes, higher body mass index (BMI), and longitudinal weight gain. Despite most of the clinical features of PCOS being risk factors for worsened infant outcomes in the general population, their impact on infant outcomes in PCOS is unknown. We aimed to investigate the association of PCOS with infant outcomes considering maternal adiposity, other known risk factors, and potential confounders. The meta-analyses included 42 studies in 7041 women with PCOS and 63 722 women without PCOS. PCOS was associated with higher gestational weight gain (GWG) and with higher preterm birth and large for gestational age and with lower birth weight with this association varying by geographic continent, PCOS phenotypes, and study quality. However, PCOS was associated with none of these outcomes on BMI-matched studies. Gestational diabetes was significantly associated with an increased preterm birth on meta-regression. We report for the first time that GWG is higher in PCOS. Infant outcomes vary by geographic continent and study quality but are similar in BMI-matched women with and without PCOS. This suggests that infant outcomes in PCOS may be related to maternal o...Continue Reading

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Citations

Nov 2, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Suhail A R DoiLukman Thalib
Oct 19, 2019·Pediatric Research·Selma Feldman WitchelAlexia S Peña
Dec 13, 2019·Journal of Diabetes Research·Ulla KampmannPer Ovesen
Nov 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Kathleen M HoegerTerhi Piltonen
Aug 18, 2020·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L Bovbjerg
Feb 9, 2021·Journal of Perinatal Medicine·Dzhamilyat AbdulkhalikovaHelena Ban Frangez
Feb 23, 2021·Therapeutic Advances in Reproductive Health·Jessica A GriegerLisa J Moran
Apr 20, 2021·Seminars in Reproductive Medicine·Stephanie PirottaLisa J Moran
Dec 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Yuexin GanJian Zhao

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