The role of matrix metalloproteinases -9 and -2 in development of neonatal chronic lung disease

Acta Paediatrica
D G SweetJ A Warner

Abstract

Matrix metalloproteinases (MMPs) -9 and -2 degrade type-IV collagen, a major constituent of lung basement membrane, and may have a role in the pathogenesis of neonatal chronic lung disease (CLD). We determined factors influencing MMP levels in neonatal bronchoalveolar lavage (BAL) fluid to establish whether an imbalance between MMP and its inhibitor could be implicated in CLD. We measured MMP-9 and -2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in 316 BAL fluid samples from 121 babies of gestational ages 23 to 42 wk over the first 14 d of life to determine effects of gestation and postnatal age. Median MMP-9, -2, TIMP-1 and MMP-9/TIMP-1 ratio in BAL were further studied in a subgroup of 85 babies <33 wk gestation to determine their ability to predict CLD and to establish effects of antenatal corticosteroid therapy (ANCS). MMP-9, -2 and TIMP levels did not vary with postnatal age over the first week. Median MMP-9 levels and MMP-9/TIMP-1 ratio increased with decreasing gestation in preterm babies. The MMP-9/TIMP-1 ratio was higher in babies who developed CLD, implying a proteinase/antiproteinase imbalance, but this association disappeared when controlled for gestational age. ANCS had no effect on BAL fluid MMP or ...Continue Reading

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Citations

Jul 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anne ChettyHeber C Nielsen
Jan 11, 2011·American Journal of Respiratory Cell and Molecular Biology·Anantha HarijithVineet Bhandari
Oct 5, 2013·Expert Review of Respiratory Medicine·Rodney D BrittY S Prakash
Jan 19, 2016·Frontiers in Medicine·Ivana Mižíková, Rory E Morty
May 1, 2010·Seminars in Fetal & Neonatal Medicine·Vineet Bhandari
Sep 10, 2015·Pediatric Research·Valérie DénervaudMatthias Roth-Kleiner
Feb 11, 2009·Pediatric Pulmonology·Shinnosuke FukunagaSusumu Furukawa
Dec 8, 2016·Pediatric Research·Elizabeth R VogelChristina M Pabelick
Nov 15, 2007·Reproductive Sciences·Julia V CockleNicolas M Orsi
Mar 18, 2021·Disease Models & Mechanisms·Kiersten GiustoChristine Finck

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