The role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation.

Journal of Applied Physiology
Matthew R Hodges, George B Richerson

Abstract

The functional roles of the medullary raphé, and specifically 5-HT neurons, are not well understood. It has previously been stated that the role of 5-HT has been so difficult to understand, because "it is implicated in virtually everything, but responsible for nothing"(Cowen PJ. Foreword. In: Serotonin and Sleep: Molecular, Functional and Clinical Aspects, edited by Monti JM, Prandi-Perumal SR, Jacobs BL, Nutt DJ. Switzerland: Birkhauser, 2008). Are 5-HT neurons important, and can we assign a general, or even specific, function to them given their diffuse projections? Recent data obtained from transgenic animals and other model systems indicate that the 5-HT system is not expendable, particularly during postnatal development, and likely plays specific roles in vital functions such as respiratory and thermoregulatory control. We recently provided a detailed and updated review of one specific function of 5-HT neurons, as central respiratory chemoreceptors contributing to the brain's ability to detect changes in pH/CO2 and stimulate adjustments to ventilation accordingly (9). Here, we turn our focus to recent data demonstrating that 5-HT neurons provide an essential excitatory drive to the respiratory network. We then further disc...Continue Reading

References

Aug 1, 1979·The Journal of Clinical Investigation·E B OlsonD R McCrimmon
Dec 1, 1990·Canadian Journal of Physiology and Pharmacology·J P MortolaA M Lauzon
May 1, 1987·The Journal of Pediatrics·C E Hunt, R T Brouillette
Dec 1, 1981·Acta Physiologica Scandinavica·Y YamamotoC von Euler
Mar 1, 1983·Acta Physiologica Scandinavica·J HednerJ Jonason
Jan 1, 1996·Journal of Applied Physiology·D G BernardE E Nattie
Aug 26, 1998·The Journal of Physiology·W WangG B Richerson
Apr 28, 1999·Neuroscience·W Wang, G B Richerson
Mar 15, 2001·Journal of Applied Physiology·E E Nattie, A Li
May 16, 2001·Journal of Neurophysiology·W WangG B Richerson
Dec 12, 2001·Respiration Physiology·G B RichersonS R Bradley
Dec 12, 2001·Respiration Physiology·M A HaxhiuS O Mack
Apr 23, 2002·Nature Neuroscience·S R BradleyG B Richerson
Jul 3, 2002·Respiratory Physiology & Neurobiology·Gina PeteEstelle B Gauda
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Polina Fenik, Sigrid C Veasey
Sep 5, 2003·Cell and Tissue Research·Britta Engelhardt
Oct 1, 2003·Nature Neuroscience·Christopher A SeversonGeorge B Richerson
Dec 16, 2003·Journal of Applied Physiology·M R HodgesH V Forster
Mar 16, 2004·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Shaun F Morrison
May 21, 2004·Nature Reviews. Neuroscience·George B Richerson
Aug 24, 2004·Journal of Applied Physiology·M R HodgesH V Forster
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fernando Peña, Jan-Marino Ramirez
Feb 25, 2005·Experimental Physiology·G B RichersonA Diez-Sampedro
Feb 24, 2006·Journal of Neurophysiology·Ivo F BrandesEckehard A E Stuth
Mar 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew K TrybaJan-Marino Ramirez
Jun 24, 2006·Journal of Applied Physiology·S E DavisH V Forster
Nov 2, 2006·JAMA : the Journal of the American Medical Association·David S PatersonHannah C Kinney
Nov 23, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rajamanickam BaskarPhilip Keith Moore
Dec 8, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhong-Qiu ZhaoZhou-Feng Chen

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Citations

Oct 27, 2012·Biogerontology·Sara FidalgoShona H Wood
Jan 19, 2011·Epilepsia·George B Richerson, Gordon F Buchanan
Feb 13, 2010·Journal of Applied Physiology·Jay B Dean, Eugene E Nattie
Nov 13, 2010·Journal of Applied Physiology·Eugene Nattie
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephen B G AbbottPatrice G Guyenet
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seth D DepuyPatrice G Guyenet
May 31, 2014·Respiratory Physiology & Neurobiology·Bryan P MosherMichael B Harris
Jul 9, 2011·Pflügers Archiv : European journal of physiology·Glauber S F da SilvaMogens L Glass
Dec 18, 2013·Neuroscience·K E Iceman, M B Harris
Apr 24, 2013·Respiratory Physiology & Neurobiology·Patrice G Guyenet, Stephen B G Abbott
Mar 5, 2013·Respiratory Physiology & Neurobiology·Matthew R HodgesGary C Mouradian
Oct 24, 2012·Brain Research·Patrice G GuyenetRuth L Stornetta
Jun 12, 2012·Respiratory Physiology & Neurobiology·Robert A Darnall
Aug 10, 2010·Seminars in Cell & Developmental Biology·Christo GoridisJean-François Brunet
Mar 24, 2010·Respiratory Physiology & Neurobiology·Christo Goridis, Jean-François Brunet
Mar 17, 2010·Respiratory Physiology & Neurobiology·Matthew R Hodges, George B Richerson
Dec 24, 2015·Sleep Medicine Reviews·Melissa C LipfordRayleigh Ping-Ying Chiang
May 23, 2013·Journal of Neurochemistry·Caitlin A MasseyKathryn G Commons
Jan 21, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Olivier FlabeauPierre-Olivier Fernagut
Apr 8, 2015·Respiratory Physiology & Neurobiology·Tomislav RadocajEdward J Zuperku
Apr 9, 2013·Autonomic Neuroscience : Basic & Clinical·Ida J Llewellyn-Smith, Patrick J Mueller
Apr 2, 2011·Respiratory Physiology & Neurobiology·Matthew R HodgesGeorge B Richerson
Feb 7, 2014·Sleep·Michael F PrestiEduardo E Benarroch
May 23, 2014·Frontiers in Cellular Neuroscience·Edison Pablo ReyesMauricio Antonio Retamal

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