The role of melatonin in immuno-enhancement: potential application in cancer.

International Journal of Experimental Pathology
Sandra C MillerG J Maestroni

Abstract

Melatonin, a neurohormone produced mainly by the pineal gland, is a modulator of haemopoiesis and of immune cell production and function, both in vivo and in vitro. Physiologically, melatonin is associated with T-helper 1 (Th1) cytokines, and its administration favours Th1 priming. In both normal and leukaemic mice, melatonin administration results in quantitative and functional enhancement of natural killer (NK) cells, whose role is to mediate defenses against virus-infected and cancer cells. Melatonin appears to regulate cell dynamics, including the proliferative and maturational stages of virtually all haemopoietic and immune cells lineages involved in host defense - not only NK cells but also T and B lymphocytes, granulocytes and monocytes - in both bone marrow and tissues. In particular, melatonin is a powerful antiapoptotic signal promoting the survival of normal granulocytes and B lymphocytes. In mice bearing mid-stage leukaemia, daily administration of melatonin results in a survival index of 30-40% vs. 0% in untreated mice. Thus, melatonin seems to have a fundamental role as a system regulator in haemopoiesis and immuno-enhancement, appears to be closely involved in several fundamental aspects of host defense and has t...Continue Reading

References

Apr 1, 1991·Journal of Pineal Research·M Giordano, M S Palermo
Jan 1, 1988·Annals of the New York Academy of Sciences·G J MaestroniW Pierpaoli
Apr 1, 1995·Current Opinion in Immunology·F MelchersJ Andersson
Apr 1, 1995·Journal of Pineal Research·J R CalvoJ M Guerrero
Mar 1, 1994·Biological Signals·A M PoonS F Pang
Feb 1, 1994·Immunological Reviews·P W KincadeG Smithson
Jan 1, 1993·Advances in Immunology·A Rolink, F Melchers
Dec 1, 1995·European Journal of Endocrinology·E WajsD Gupta
Nov 1, 1995·Journal of Pineal Research·R M SainzA Menendez-Pelaez
Sep 9, 1996·Mechanisms of Ageing and Development·M ProvincialiN Fabris
May 1, 1997·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D PozoJ M Guerrero
May 19, 1998·Nature Medicine·D M Pardoll
May 20, 1998·Biological Signals·F FraschiniF Scaglione
Jun 4, 1998·Biochemical and Biophysical Research Communications·T YamaguchiE M Brown
Jun 26, 1998·Biological Signals and Receptors·F FraschiniF Scaglione
Jul 1, 1998·International Reviews of Immunology·N Petrovsky, L C Harrison
Sep 24, 1998·Journal of Pineal Research·T H ChampneyL A Beausang
Aug 14, 1999·Scandinavian Journal of Immunology·P FiorinaP Dall'Aglio
Dec 1, 1999·Life Sciences·S García-MauriñoJ M Guerrero
Mar 14, 2000·Journal of Neuroimmunology·N L CurrierS C Miller
Jun 1, 2000·Journal of Pineal Research·A ContiJ M Maestroni
Jun 3, 2000·Annual Review of Immunology·L Fong, E G Engleman
Sep 12, 2000·Journal of Pineal Research·Q YuD G Osmond
Feb 28, 2001·Expert Opinion on Investigational Drugs·G J Maestroni
Mar 16, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M M AnwarA S Sayed
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D L DrazenR J Nelson

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Citations

Aug 1, 2012·Clinical Oral Investigations·Kristina BertlXiaohui Rausch-Fan
Jun 2, 2007·Breast Cancer Research and Treatment·V SrinivasanG J Maestroni
Jul 1, 2011·Medical & Biological Engineering & Computing·Yang MengTianhao Zhang
May 19, 2012·International Journal of Inflammation·Jolanta JaworekMichalina Kot
Jul 14, 2012·International Journal of Dentistry·Murat İnanç CengizHom-Lay Wang
Aug 29, 2012·International Journal of Dentistry·Fanny López-MartínezRicardo Martínez Pedraza
Aug 18, 2012·International Journal of Dentistry·V K Chava, K Sirisha
Nov 23, 2006·Neuroimmunomodulation·Aglaia Giannoulia-KarantanaGeorge P Chrousos
Jun 2, 2007·Journal of Periodontology·Antonio CutandoRussel J Reiter
Oct 26, 2011·World Journal of Gastroenterology : WJG·Chun-Qiu ChenMartin Storr
Apr 22, 2014·International Journal of Molecular Sciences·Sara SalucciElisabetta Falcieri
Jan 5, 2014·Inflammation·Katharina Effenberger-NeidnichtHerbert de Groot
Aug 6, 2014·International Journal of Molecular Sciences·Lucia MarsegliaEloisa Gitto
Sep 6, 2011·Molecular and Cellular Endocrinology·Dave LanoixCathy Vaillancourt
Mar 10, 2016·Pharmaceutical Research·Ana FloBeatriz Clares
Dec 15, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A Muñoz-HoyosM J Gutiérrez-Salmerón
Jul 25, 2007·Journal of Pineal Research·Ana García-NavarroDarío Acuña-Castroviejo
Mar 15, 2008·Journal of Pineal Research·Flavia RadognaLina Ghibelli
Feb 26, 2008·British Journal of Clinical Pharmacology·Georges J MaestroniMaurizio Cutolo
Jul 31, 2013·Journal of Pineal Research·Juan R CalvoM D Maldonado
Oct 2, 2009·Clinical Implant Dentistry and Related Research·Fernando MuñozAntonio Cutando
Jul 15, 2011·Journal of Pineal Research·Virginia MotilvaMatilde Illanes
Jan 23, 2015·Journal of Pineal Research·Vânia BrazãoJosé Clóvis do Prado
Aug 18, 2009·Oral Diseases·G Gómez-MorenoR J Reiter
Jul 6, 2013·Acta Microbiologica Et Immunologica Hungarica·György Csaba
May 12, 2012·Molecular and Cellular Endocrinology·Ana Coto-MontesRussel J Reiter
Aug 16, 2016·The Kaohsiung Journal of Medical Sciences·Shariq NajeebMuhammad Sohail Zafar
May 10, 2017·International Journal of Molecular Sciences·Ahmed Esmat Abdel MoneimGermaine Escames
Jun 7, 2017·American Journal of Reproductive Immunology : AJRI·Gene Chi Wai ManTin Chiu Li
Jun 8, 2017·International Journal of Molecular Sciences·Hoon JangYoungsok Choi
Nov 26, 2010·Pharmacological Reports : PR·Jolanta JaworekRomana Tomaszewska
Mar 1, 2017·Clinical Reviews in Allergy & Immunology·J Torres-RuizY Shoenfeld
Apr 1, 2017·Scientific Reports·Yasmine M CisséRandy J Nelson
Sep 26, 2008·Integrative Cancer Therapies·Venkataramanujan SrinivasanDaniel P Cardinali
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wamidh H Talib
Jan 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marino B Arnao, Josefa Hernández-Ruiz
Mar 2, 2018·American Journal of Reproductive Immunology : AJRI·Hui-Li YangMing-Qing Li
Oct 24, 2017·Archives of Physiology and Biochemistry·Saltuk Bugra BaltaciHasibe Artac
Sep 22, 2018·Journal of Cellular Physiology·Bagher FarhoodAmirhossein Sahebkar
Sep 30, 2017·PloS One·Jiunn-Diann LinChao-Wen Cheng

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