The role of melatonin in the neurodevelopmental etiology of schizophrenia: A study in human olfactory neuronal precursors

Journal of Pineal Research
T Galván-ArrietaG Benítez-King

Abstract

Dim light exposure of the mother during pregnancy has been proposed as one of the environmental factors that affect the fetal brain development in schizophrenia. Melatonin circulating levels are regulated by the environmental light/dark cycle. This hormone stimulates neuronal differentiation in the adult brain. However, little is known about its role in the fetal human brain development. Olfactory neuronal precursors (ONPs) are useful for studying the physiopathology of neuropsychiatric diseases because they mimic all the stages of neurodevelopment in culture. Here, we first characterized whether melatonin stimulates neuronal differentiation in cloned ONPs obtained from a healthy control subject (HCS). Then, melatonin effects were evaluated in primary cultures of ONPs derived from a patient diagnosed with schizophrenia (SZ) and an age- and gender-matched HCS. Axonal formation was evidenced morphologically by tau immunostaining and by GSK3β phosphorylated state. Potassium-evoked secretion was assessed as a functional feature of differentiated neurons. As well, we report the expression of MT1/2 receptors in human ONPs for the first time. Melatonin stimulated axonal formation and ramification in cloned ONPs through a receptor-medi...Continue Reading

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Citations

Jul 14, 2017·International Journal of Molecular Sciences·Montserrat G CercósCitlali Trueta
Sep 15, 2018·Endocrine Reviews·José Cipolla-Neto, Fernanda Gaspar do Amaral
Aug 6, 2020·Psychiatry Investigation·Simge Seren Kirlioglu, Yasin Hasan Balcioglu
Aug 8, 2018·International Journal of Molecular Sciences·Rosa Estrada-ReyesGloria Benítez-King
May 9, 2019·Stem Cells International·Héctor Solís-ChagoyánGloria A Benítez-King
Jul 26, 2018·International Journal of Molecular Sciences·Leonor Mendoza-VargasHéctor Solís-Chagoyán
Mar 29, 2020·Biomédica : revista del Instituto Nacional de Salud·Carlos Ayala-GrossoJosé E Cardier
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Héctor Solís-ChagoyánGloria Benítez-King
May 29, 2021·Neurochemistry International·Eylem BaysalN Dilara Zeybek

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