The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer.

Amino Acids
Robert B Hamanaka, Gökhan M Mutlu

Abstract

Fibrosis is a pathologic condition resulting from aberrant wound healing responses that lead to excessive accumulation of extracellular matrix components, distortion of organ architecture, and loss of organ function. Fibrotic disease can affect every organ system; moreover, fibrosis is an important microenvironmental component of many cancers, including pancreatic, cervical, and hepatocellular cancers. Fibrosis is also an independent risk factor for cancer. Taken together, organ fibrosis contributes to up to 45% of all deaths worldwide. There are no approved therapies that halt or reverse fibrotic disease, highlighting the great need for novel therapeutic targets. At the heart of almost all fibrotic disease is the TGF-β-mediated differentiation of fibroblasts into myofibroblasts, the primary cell type responsible for the production of collagen and other matrix proteins and distortion of tissue architecture. Recent advances, particularly in the field of lung fibrosis, have highlighted the role that metabolic reprogramming plays in the pathogenic phenotype of myofibroblasts, particularly the induction of de novo amino acid synthesis pathways that are required to support collagen matrix production by these cells. In this review, w...Continue Reading

References

Jun 1, 1978·Metabolism: Clinical and Experimental·R J Smith, J M Phang
Sep 1, 1975·The Biochemical Journal·T F Shen, H J Strecker
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A B RobertsJ H Kehrl
Nov 8, 1985·Science·D S DolbergM J Bissell
Mar 1, 1973·In Vitro·N Blumenkrantz, G Asboe-Hansen
Apr 1, 1973·The Biochemical Journal·M AaltoE Kulonen
Oct 15, 1970·Biochimica Et Biophysica Acta·M Rojkind, L Diaz de León
Dec 1, 1970·The Journal of Clinical Investigation·D KershenobichM Rojkind
Aug 15, 1981·The Biochemical Journal·J N HildebranR B Low
Jun 11, 2002·Annual Review of Nutrition·Sidney M Morris
Apr 8, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Motoyoshi EndoTomomi Gotoh
Jan 4, 1965·Biochimica Et Biophysica Acta·S TSURUFUJI, Y MORI
Oct 16, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kamila KitowskaOliver Eickelberg
Nov 27, 2007·Free Radical Biology & Medicine·Navasona KrishnanDonald F Becker
Apr 7, 2009·Annual Review of Biochemistry·Matthew D Shoulders, Ronald T Raines
Aug 25, 2009·Nature Medicine·Louise HeckerVictor J Thannickal
Dec 29, 2009·Trends in Plant Science·László Szabados, Arnould Savouré
May 1, 2010·Trends in Biochemical Sciences·Robert B Hamanaka, Navdeep S Chandel
Mar 23, 2011·Cold Spring Harbor Perspectives in Biology·Sylvie Ricard-Blum
Mar 8, 2012·Nature Reviews. Molecular Cell Biology·Riekelt H HoutkooperJohan Auwerx
Mar 16, 2012·NMR in Biomedicine·Elizabeth A MaherRalph J DeBerardinis
Apr 17, 2012·PloS One·Einat I RabinovichNaftali Kaminski
Jun 16, 2012·American Journal of Respiratory and Critical Care Medicine·Yan Y SandersJames S Hagood
Dec 4, 2012·The Journal of Biological Chemistry·Manu JainNavdeep S Chandel
Jul 17, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas R Cox, Janine T Erler
Sep 5, 2014·Cancer Discovery·Jiangbin YeCraig B Thompson
Feb 24, 2015·Nature Genetics·Alexandre CalonEduard Batlle
Mar 19, 2015·The New England Journal of Medicine·Don C RockeyJoseph A Hill
Aug 19, 2015·American Journal of Respiratory and Critical Care Medicine·Na XieGang Liu
Sep 1, 2015·The Journal of Biological Chemistry·Karen BernardVictor J Thannickal
Dec 3, 2015·Current Opinion in Chemical Biology·Xiaoyang SuJoshua D Rabinowitz
Dec 19, 2015·Cellular and Molecular Life Sciences : CMLS·Ian A DarbyAlexis Desmoulière
Feb 9, 2016·Cell·Christopher T HensleyRalph J DeBerardinis
Feb 9, 2016·Cell Metabolism·Shawn M DavidsonMatthew G Vander Heiden
Apr 8, 2016·Journal of Proteome Research·Yun Pyo KangSung-Woo Park
May 11, 2016·Molecular Genetics and Metabolism·Ayman W El-Hattab

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