The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity

Trends in Immunology
R F Wang

Abstract

The identification of tumor antigens has generated a resurgence of interest in immunotherapy for cancer. However, both clinical and animal studies suggest that therapeutic strategies that have mainly focused on the use of CD8+ T cells (and MHC class I-restricted tumor antigens) are not effective in eliminating cancer cells. Recent interest has been directed towards the use of CD4+ T cells in generating antitumor immunity. To this end, the identification of MHC class II-restricted tumor antigens that can stimulate CD4+ T cells might provide opportunities for developing effective cancer vaccines.

References

Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·M J MattesK O Lloyd
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·S SandersonN Shastri
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y KawakamiS A Rosenberg
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y KawakamiS A Rosenberg
Mar 1, 1996·The Journal of Experimental Medicine·R F WangS A Rosenberg
Mar 1, 1996·The Journal of Experimental Medicine·P F RobbinsS A Rosenberg
May 1, 1996·The Journal of Experimental Medicine·S L TopalianP F Robbins
Sep 1, 1996·Scientific American·L J Old
Dec 1, 1996·The Journal of Experimental Medicine·R F WangS A Rosenberg
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y T ChenL J Old
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·J van BergenF Koning
Aug 29, 1997·The Journal of Experimental Medicine·S MandruzzatoP van der Bruggen
Mar 11, 1998·Current Opinion in Immunology·A O'GarraK Gijbels
May 23, 1998·The Journal of Experimental Medicine·E StockertL J Old
Aug 15, 1998·Critical Reviews in Immunology·P A Morel, T B Oriss
Aug 26, 1998·Current Biology : CB·P L Felgner
Sep 22, 1998·The Journal of Experimental Medicine·G S OggV Cerundolo
Oct 24, 1998·Critical Reviews in Immunology·W C Lai, M Bennett
Oct 31, 1998·Current Opinion in Immunology·D M Pardoll, S L Topalian
Dec 22, 1998·The Journal of Experimental Medicine·S A Kalams, B D Walker
Dec 22, 1998·The Journal of Experimental Medicine·K HungH Levitsky
Mar 2, 1999·The Journal of Experimental Medicine·R E ToesC J Melief
Mar 2, 1999·The Journal of Experimental Medicine·R PieperS L Topalian
Mar 2, 1999·The Journal of Experimental Medicine·P ChauxP van der Bruggen
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·W W OverwijkN P Restifo
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D MumbergH Schreiber
Oct 8, 1999·Immunity·E Gilboa

❮ Previous
Next ❯

Citations

Aug 4, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Akshata Udyavar, Terrence L Geiger
Mar 24, 2006·Cancer Immunology, Immunotherapy : CII·Deepak P AssudaniRobert C Rees
Feb 3, 2009·Cancer Immunology, Immunotherapy : CII·Kazuaki ChikamatsuKeisuke Masuyama
Mar 1, 2012·Cancer Immunology, Immunotherapy : CII·Jing ZhangXiubao Ren
Jul 27, 2007·Breast Cancer Research and Treatment·Carsten T ViehlPeter S Goedegebuure
Mar 30, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Roberto Mallone, Gerald T Nepom
Mar 19, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A A AliC S McArdle
May 27, 2004·Vaccine·Aleksandra LenarczykAndreas Suhrbier
Dec 4, 2003·Biochimica Et Biophysica Acta·Simone MocellinFrancesco M Marincola
Aug 6, 2003·Current Opinion in Immunology·Alessandro Sette, John Fikes
Feb 14, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marcela V MausCarl H June
Feb 3, 2005·Nature Reviews. Microbiology·Rosemary RochfordAnn M Moormann
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yoshihiro MiyaharaRong-Fu Wang
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·H NishikawaH Shiku
Feb 17, 2010·The Journal of Experimental Medicine·Ying XiePaul Andrew Antony
Sep 21, 2004·Journal of Gastroenterology and Hepatology·Sun-Lung Tsai
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael J CallahanSamuel C Mok
Jan 4, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mikiko FukuiYuji Hinoda
Mar 6, 2007·Neuroimmunomodulation·Saleh Mohaghegh HazratiArmin Rashidi
Apr 16, 2004·The Journal of Clinical Investigation·Maha AyyoubDanila Valmori
May 4, 2007·The Journal of Clinical Investigation·Eli Gilboa
Nov 16, 2010·Clinical & Developmental Immunology·Hanka JähnischMarc Schmitz
Aug 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hiroyoshi NishikawaHiroshi Shiku
Mar 9, 2012·Clinical & Developmental Immunology·Trudy StraetemansReno Debets
May 15, 2010·Journal of Biomedicine & Biotechnology·Marc CartellieriMarc Schmitz
Apr 25, 2014·Expert Review of Vaccines·Laetitia CiccheleroNiek N Sanders
Aug 29, 2003·Expert Opinion on Biological Therapy·John D Fikes, Alessandro Sette
Dec 19, 2003·Expert Opinion on Biological Therapy·Graham S Taylor
Aug 27, 2005·Expert Opinion on Biological Therapy·Gavin M BendleHans J Stauss
Nov 26, 2003·International Journal of Cancer. Journal International Du Cancer·Hanno EhlkenStefan Eichmüller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.