The Role of Microglia in Perioperative Neuroinflammation and Neurocognitive Disorders.

Frontiers in Aging Neuroscience
Sarah SaxenaMervyn Maze

Abstract

The aseptic trauma of peripheral surgery activates a systemic inflammatory response that results in neuro-inflammation; the microglia, the resident immunocompetent cells in the brain, are a key element of the neuroinflammatory response. In most settings microglia perform a surveillance role in the brain detecting and responding to "invaders" to maintain homeostasis. However, microglia have also been implicated in producing harm possibly by changing its phenotype from its beneficial, anti-inflammatory state (termed M2) into an injurious pro-inflammatory state (termed M1); it is likely that there are intermediates states between these polar phenotypes and some consider that a gradient exists with a number of intermediates, rather than a strict dichotomy between M1 and M2. In the pro-inflammatory phenotypes, microglia can disrupt synaptic plasticity such as long- term potentiation that can result in disorders of learning and memory of the type observed in Peri-operative Neurocognitive Disorders. Therefore, investigators have sought strategies to prevent microglia from provoking this adverse event in the perioperative period. In preclinical studies microglia can be depleted by removing trophic factors required for its maintenance; ...Continue Reading

References

Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·R B BanatiS B Blunt
May 5, 2000·Neurobiology of Aging·Y M ArendsJ J Hauw
Mar 30, 2004·Nature Neuroscience·Jackie Yuanyuan Hua, Stephen J Smith
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie K Olson, Stephen D Miller
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carolyn S JackJack P Antel
Jun 3, 2006·Science·Séverine BoilléeDon W Cleveland
Sep 15, 2007·Journal of Neuroimmunology·Seija LehnardtJoerg R Weber
Oct 30, 2007·Nature Neuroscience·Uwe-Karsten Hanisch, Helmut Kettenmann
Jun 24, 2008·Brain : a Journal of Neurology·H NeumannR J M Franklin
Sep 19, 2008·Expert Opinion on Drug Metabolism & Toxicology·Gaylia Jean Harry, Andrew D Kraft
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hiroaki WakeJunichi Nabekura
Aug 20, 2009·Current Topics in Medicinal Chemistry·Sharmila Patel, Mark R Player
Sep 10, 2009·Frontiers in Behavioral Neuroscience·Staci D Bilbo, Jaclyn M Schwarz
Sep 8, 2010·Annals of Neurology·Mario CibelliMervyn Maze
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Niccolò TerrandoMervyn Maze
Jul 16, 2011·Developmental Neuroscience·Melinda CzehAngela M Kaindl
Jul 23, 2011·Science·Rosa C PaolicelliCornelius T Gross
Dec 23, 2011·Annals of Neurology·Niccolò TerrandoMervyn Maze
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maki HoshikoEtienne Audinat
Jan 15, 2013·Neuron·Helmut KettenmannAlexei Verkhratsky
Oct 4, 2013·Neural Plasticity·Francesco Ferrini, Yves De Koninck
Aug 28, 2014·Cell Reports·Paola SquarzoniSonia Garel
Dec 4, 2014·Nature·Elisa Gomez PerdigueroHans-Reimer Rodewald
Jan 20, 2015·Molecular Neurobiology·Yu Tang, Weidong Le
Jul 4, 2015·Neuron·Jun Nishiyama, Ryohei Yasuda
Jul 15, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rachel A RiceKim N Green
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yi-Je ChenHeike Wulff
Feb 3, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Robert A SchoeversRudie Kortekaas
May 26, 2016·Journal of Neuroinflammation·Charles C KimChristine L Hsieh
Jul 28, 2016·Nature Neuroscience·Richard M Ransohoff
Sep 7, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Minshu LiFu-Dong Shi

❮ Previous
Next ❯

Citations

Aug 8, 2021·International Journal of Molecular Sciences·Bhakta Prasad Gaire, Ji-Woong Choi

❮ Previous
Next ❯

Software Mentioned

ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.