The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4

Biochemical and Biophysical Research Communications
Guo-Jun WangXiefu Zhang

Abstract

MicroRNAs (miRNAs) are a series of 18-25 nucleotides length non-coding RNAs, which play critical roles in tumorigenesis. Previous study has shown that microRNA-1274a (miR-1274a) is upregulated in human gastric cancer. However, its role in gastric cancer progression remains poorly understood. Therefore, the current study was aimed to examine the effect of miR-1274a on gastric cancer cells. We found that miR-1274a was overexpressed in gastric cancer tissues or gastric cancer cells including HGC27, MGC803, AGS, and SGC-7901 by qRT-PCR analysis. Transfection of miR-1274a markedly promoted gastric cancer cells proliferation and migration as well as induced epithelial-mesenchymal transition (EMT) of cancer cells. Our further examination identified FOXO4 as a target of miR-1274a, which did not influence FOXO4 mRNA expression but significantly inhibited FOXO4 protein expression. Moreover, miR-1274a overexpression activated PI3K/Akt signaling and upregulated cyclin D1, MMP-2 and MMP-9 expressions. With tumor xenografts in mice models, we also showed that miR-1274a promoted tumorigenesis of gastric cancer in vivo. In all, our study demonstrated that miR-1274a prompted gastric cancer cells growth and migration through dampening FOXO4 expr...Continue Reading

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Citations

Jan 8, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan ZhaoShuixiang He
Jul 18, 2015·Redox Biology·Lars-Oliver KlotzMaria Monsalve
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Aug 25, 2021·Molecular Biotechnology·Shi-Jia ZhuJian-Yu Xu
Oct 12, 2021·Journal of Ovarian Research·Arash Adamnejad GhafourHulya Yazici

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