The role of microRNA in esophageal squamous cell carcinoma

Journal of Gastroenterology
Kazuto HaradaHideo Baba

Abstract

MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3'-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.

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Citations

Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Maryam HemmatzadehBehzad Baradaran
Apr 22, 2017·Genetic Testing and Molecular Biomarkers·Ziba Nariman-Saleh-FamJavad Tavakkoly-Bazzaz
Jan 24, 2019·Biomarkers in Medicine·Ziba Nariman-Saleh-FamJavad Tavakkoli-Bazzaz
Oct 27, 2018·Journal of Cellular Biochemistry·Ya-Tian LiuXia He
Jun 27, 2020·The Journal of International Medical Research·Lingmin ZhangMingxin Zhang
Mar 11, 2020·Frontiers in Bioengineering and Biotechnology·Haiyong WangGuangmao Yu

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