The role of microRNAs in bone development.

Bone
Austin P Hensley, Audrey McAlinden

Abstract

Epigenetic regulation is critical for proper bone development. Evidence from a large body of published literature informs us that microRNAs (miRNAs) are important epigenetic factors that control many aspects of bone development, homeostasis, and repair processes. These small non-coding RNAs function at the post-transcriptional level to suppress expression of specific target genes. Many target genes may be affected by one miRNA resulting in alteration in cellular pathways and networks. Therefore, changes in levels or activity of a specific miRNA (e.g. via genetic mutations, disease scenarios, or by over-expression or inhibition strategies in vitro or in vivo) can lead to substantial changes in cell processes including proliferation, metabolism, apoptosis and differentiation. In this review, Section 1 briefly covers general background information on processes that control bone development as well as the biogenesis and function of miRNAs. In Section 2, we discuss the importance of miRNAs in skeletal development based on findings from in vivo mouse models and human clinical reports. Section 3 focuses on describing more recent data from the last three years related to miRNA regulation of osteoblast differentiation in vitro. Some of ...Continue Reading

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Citations

Dec 2, 2020·International Journal of Molecular Sciences·Massimo De MartinisSebastiano Gangemi
Mar 7, 2021·International Journal of Molecular Sciences·Chiara MazziottaFernanda Martini
May 19, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John GarciaAnne M Delany
Jun 3, 2021·International Journal of Molecular Sciences·Wilson Cheuk Wing ChanDanny Chan

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