The role of microRNAs in prostate cancer progression

Translational Andrology and Urology
U-Ging LoJer-Tsong Hsieh

Abstract

Prostate cancer (PCa) is the most common male malignancy and the second highest cause of cancer-related mortality in United States. MicroRNAs (miRNAs) are small non-coding RNAs that represent a new mechanism to regulate mRNA post-transcriptionally. It is involved in diverse physiological and pathophysiological process. Dysregulation of miRNAs has been associated with the multistep progression of PCa from prostatic intraepithelial neoplasia (PIN), localized adenocarcinoma to metastatic castration-resistance PCa (CRPC). Identification of unique miRNA could provide new biomarkers for PCa and develop into therapeutic strategies. In this review, we will summarize a broad spectrum of both tumor suppressive and oncogenic miRNAs, and their mechanisms contribute to prostate carcinogenesis.

Citations

Nov 29, 2016·Prostate Cancer·Mankgopo M KgatleRazia Moorad
May 27, 2020·Mediators of Inflammation·Wei JinFangjie Chen
Feb 18, 2021·Biomedical Engineering Online·Leonardo J Galvão-LimaElio J S S Barreto
Apr 4, 2021·Pharmaceutics·Noemi Arrighetti, Giovanni Luca Beretta

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