The role of miR-92b in cholangiocarcinoma patients

The International Journal of Biological Markers
Min-Hang ZhouJun-Zhong Sun

Abstract

The role of microRNA (miRNA) in cholangiocarcinoma was not clear. The aim of this study was to find the potential diagnostic and prognostic miRNA in cholangiocarcinoma patients. The miRNA expression profiles in cholangiocarcinoma patients from The Cancer Genome Atlas and Gene Expression Omnibus (GSE53870) were analyzed. The comparison of overall survival was performed using the Kaplan-Meier method. The targeted genes of prognostic miRNA were identified in miRanda, PicTar, or TargetScan, and their cell signaling pathways were analyzed by the Database for Annotation, Visualization and Integrated Discovery. In The Cancer Genome Atlas and the Gene Expression Omnibus miRNA dataset, miR-92b and miR-99a were found with concordant directionality, up-regulated and down-regulated, respectively. In The Cancer Genome Atlas survival data, patients with the high level of miR-99b had obviously shorter overall survival time ( P=0.038). However, the level of miR-99a was not found to be significant. The 17 shared target genes of miR-92b were identified, such as DAB21IP, BCL21L11, SPHK2, PER2, and TSC1. The related pathways included positive regulation of transcription, positive regulation of cellular biosynthetic process, regulation of programme...Continue Reading

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Citations

Sep 25, 2020·FEBS Letters·Nigel J Pyne, Susan Pyne
Mar 15, 2019·Experimental and Therapeutic Medicine·Qiang DongYawen Pan
May 11, 2021·Expert Review of Gastroenterology & Hepatology·Sven A LangUlf P Neumann

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Datasets Mentioned

BETA
GSE53870

Software Mentioned

Database for Annotation , Visualization and Integrated Discove...
limma
TargetScan
SPSS
miRanda
Bioconductor
edgeR
DAVID : Database for Annotation , Visualization and Integrated
PicTar
DAVID

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