The role of mitochondria-associated membranes in cellular homeostasis and diseases

International Review of Cell and Molecular Biology
Mariasole PerronePaolo Pinton

Abstract

Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell physiology regulating several signal transduction pathways. They continuously communicate exchanging messages in their contact sites called MAMs (mitochondria-associated membranes). MAMs are specific microdomains acting as a platform for the sorting of vital and dangerous signals. In recent years increasing evidence reported that multiple scaffold proteins and regulatory factors localize to this subcellular fraction suggesting MAMs as hotspot signaling domains. In this review we describe the current knowledge about MAMs' dynamics and processes, which provided new correlations between MAMs' dysfunctions and human diseases. In fact, MAMs machinery is strictly connected with several pathologies, like neurodegeneration, diabetes and mainly cancer. These pathological events are characterized by alterations in the normal communication between ER and mitochondria, leading to deep metabolic defects that contribute to the progression of the diseases.

Citations

Jul 7, 2020·Frontiers in Cell and Developmental Biology·Lingna XuChao Tong
Dec 20, 2020·Cell·Carlos López-Otín, Guido Kroemer
Feb 17, 2021·Cell Death & Disease·Lisenn LalierFrançois M Vallette
Feb 10, 2021·Biomedicines·Carlotta GiorgiSimone Patergnani
Nov 27, 2020·Frontiers in Neuroscience·Olesya M ShirokovaIrina V Mukhina
Mar 7, 2021·Biochemical and Biophysical Research Communications·Atsuhiro TsutiyaTomohiro Kato
Mar 13, 2021·Seminars in Cell & Developmental Biology·Sonam Parakh, Julie D Atkin
Jul 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chenrui LiLin Sun
May 6, 2021·International Journal of Molecular Sciences·Ilaria GenoveseCarlotta Giorgi
Jun 18, 2021·Frontiers in Cell and Developmental Biology·Laura M SzczesniakRichard J H Wojcikiewicz

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