The Role of Mitochondria in AMD: Current Knowledge and Future Applications

Journal of Ophthalmic & Vision Research
Mohammad Riazi-EsfahaniM Cristina Kenney

Abstract

Mitochondria are organelles which comprise the main respiratory machinery in the eukaryotic cells. In addition to their crucial role in energy production, they have profound effects on apoptosis and retrograde signaling to nucleus. Mitochondria have their own DNA, which codes for different proteins mostly involved in oxidative phosphorylation. Significant changes in the mitochondria of retinal pigment epithelium have been reported in age-related macular degeneration (AMD), which is correlated with the severity of the disease. Cybrid cell lines that have identical nuclei but mitochondria from different individuals can provide a unique means for studying the relationship between mitochondria and AMD. Different approaches for protection of mitochondria have been introduced which can be considered as potential future treatments for AMD and other age- related disorders.

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Citations

Nov 23, 2019·International Journal of Molecular Sciences·Juha M T HyttinenKai Kaarniranta
Mar 21, 2020·Signal Transduction and Targeted Therapy·Bowen WangHong Ouyang
May 20, 2020·Frontiers in Cell and Developmental Biology·Raju V S Rajala
Apr 17, 2020·Signal Transduction and Targeted Therapy·Bowen WangHong Ouyang
Feb 22, 2021·Survey of Ophthalmology·Razek Georges CoussaElias I Traboulsi

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Methods Mentioned

BETA
transmission electron microscopy

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis