PMID: 11923632Mar 30, 2002Paper

The role of mitochondria in epileptogenesis

Current Opinion in Neurology
Wolfram S Kunz

Abstract

Mitochondrial dysfunction has gained considerable interest as a potential cause of epileptic seizures and therapy-resistant forms of severe epilepsy. Impairment of mitochondrial function has recently been observed in the seizure focus of human and experimental epilepsy. Additionally, a broad variety of mutation of mitochondrial DNA leading to the inhibition of mitochondrial respiratory chain or directly of mitochondrial adenosine triphosphate synthesis in epileptogenic areas of the human brain has been associated with epileptic phenotypes. Since mitochondrial oxidative phosphorylation provides the major source of adenosine triphosphate in neurons, and mitochondria participate in cellular Ca2+ homeostasis they can modulate neuronal excitability and synaptic transmission. Furthermore, mitochondria are intimately involved in pathways leading to the neuronal cell death characteristic for the areas of epileptogenesis.

References

Jul 15, 1992·Biochemical and Biophysical Research Communications·M TaniikeK Inui
Nov 1, 1981·Stroke; a Journal of Cerebral Circulation·J AstrupH R Sørensen
Nov 22, 1995·Biochemical and Biophysical Research Communications·F M SantorelliS DiMauro
Sep 1, 1995·Neuromuscular Disorders : NMD·G ManfrediS DiMauro
Sep 5, 1995·Biochemical and Biophysical Research Communications·M NakamuraJ Kimura
Jan 1, 1993·European Journal of Human Genetics : EJHG·M ZevianiS DiDonato
Oct 1, 1993·Brain Pathology·B S Meldrum
Sep 1, 1993·Annals of Neurology·D D de VriesB A van Oost
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall
Nov 27, 1998·European Journal of Pharmacology·E M UrbanskaW A Turski
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·S KrajewskiJ C Reed
Oct 26, 1999·The Journal of Comparative Neurology·I BlümckeO D Wiestler
May 29, 2001·Neurology·L CanafogliaG Avanzini
Nov 22, 2001·Experimental Neurology·S VielhaberW S Kunz

❮ Previous
Next ❯

Citations

Jun 20, 2007·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hoon-Chul KangSi Houn Hahn
Nov 12, 2010·Journal of Bioenergetics and Biomembranes·Gábor Zsurka, Wolfram S Kunz
Feb 26, 2004·Free Radical Biology & Medicine·Li-Ping Liang, Manisha Patel
Jul 19, 2008·Neuron Glia Biology·Tianfu LiDetlev Boison
Aug 17, 2004·Epilepsy Currents·Carl E. Stafstrom
Mar 24, 2009·Brain : a Journal of Neurology·Tuula LönnqvistHelena Pihko
Mar 4, 2010·Epilepsia·Sandra El SabbaghIsabelle Desguerre
Sep 14, 2012·Epilepsia·Laurence A Bindoff, Bernt A Engelsen
May 17, 2007·Epilepsy Currents·Jong M Rho, Michael A Rogawski
May 8, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria K LehtinenAnna-Elina Lehesjoki
Feb 5, 2008·Genetics·Tim FergestadBarry Ganetzky
May 9, 2014·Revue neurologique·I DesguerreR Nabbout
May 7, 2013·Cerebral Cortex·Xiaogang ZhangXuefeng Wang
Jul 14, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E CaiettaB Chabrol
Mar 20, 2012·Epilepsy Research·Srishti NangiaIngrid E Scheffer
Sep 20, 2011·Brain & Development·Asuri N PrasadChitra Prasad
Oct 27, 2009·Brain Research Bulletin·Bianca BrawekThomas J Feuerstein
Mar 10, 2009·Experimental Neurology·Alexei P KudinWolfram S Kunz
Jul 15, 2015·Epilepsy & Behavior : E&B·Shamima Rahman
Jan 7, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Radwa A B BadawyRichard A L Macdonell
Feb 26, 2008·Neurobiology of Disease·Stuart G JarrettManisha Patel
Feb 6, 2008·Progress in Neurobiology·Detlev Boison
May 10, 2008·Journal of Neurochemistry·Stuart G JarrettManisha Patel
Jan 31, 2012·Developmental Medicine and Child Neurology·Shamima Rahman
Jun 16, 2012·Glia·Detlev Boison
Jan 18, 2006·Free Radical Biology & Medicine·Li-Ping Liang, Manisha Patel
Jun 5, 2012·Neuropharmacology·Stjepana KovacMatthew C Walker
Jul 14, 2010·Journal of the Neurological Sciences·Liang WangXuefeng Wang
May 3, 2011·Mitochondrion·Jaroslava Folbergrová, Wolfram S Kunz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.