The role of mitomycin C in reducing recurrence of epidural fibrosis after repeated operation in a laminectomy model in rats

Journal of Neurosurgery. Spine
Jin-Yul LeeNorfrid Klug

Abstract

Extensive peridural fibrosis after lumbar spine surgery may contribute to poor outcome and recurrent symptoms leading to repeated operation. Secondary procedures are considerably hampered by the presence of scar tissue. Moreover, after excision of the peridural scar, the fibrous tissue may recur, leading to unsuccessful surgical outcome. Mitomycin C (MMC), an alkylating antibiotic substance isolated from Streptomyces caespitosus, potentially suppresses fibroblast proliferation after surgical intervention. The authors investigated the effect of MMC on the reformation of epidural fibrosis in a laminectomy model in rats. Twenty-four Wistar rats underwent a repeated lumbar laminectomy 3 months after the first operation. In 12 rats, MMC in a concentration of 1 mg/ml was locally applied to the laminectomy site. No treatment was performed in the control group of the other 12 rats. All rats underwent clinical evaluation. Mobility ratings and any evidence of neurological deficit were recorded. Twelve weeks after the second operation, the animals were killed for histological examination. The extent of epidural fibrosis and dural adherence was evaluated. All MMC-treated animals showed reduced epidural scarring, compared with the control g...Continue Reading

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Citations

May 11, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Baris KocaogluMustafa Karahan
Oct 22, 2008·Journal of Neurosurgery. Spine·Suat E CelikZiya Kapran
Jun 18, 2009·British Journal of Neurosurgery·Berker CemilIbrahim Tekdemir
Jul 14, 2012·The Canadian Journal of Cardiology·Necmettin ColakOmer Cakir
May 11, 2010·European Journal of Pharmacology·Changhui SuFengchao Zang
Sep 4, 2013·The Spine Journal : Official Journal of the North American Spine Society·Mehdi ZeinalizadehZohreh Habibi
Mar 6, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xiaolei LiMing Pei
Jun 2, 2010·The Journal of Bone and Joint Surgery. British Volume·B KocaogluM Türkmen

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