Sep 23, 2011

The role of motor proteins in endosomal sorting

Biochemical Society Transactions
Sylvie D Hunt, David J Stephens

Abstract

Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them. This is well illustrated both by the vectorial transfer of biosynthetic cargo from the endoplasmic reticulum to the Golgi apparatus as well as the sorting of secretory and endocytic cargo in the endosomal system. Roles have been described for dynein and kinesin motors in each of these steps. Cytoplasmic dynein is a highly complex motor comprising multiple subunits that provide functional specialization. The family of human kinesins includes over 40 members. This complexity provides immense functional diversity, yet little is known of the specific requirements and functions of individual motors during discrete membrane trafficking steps. In the present paper, we describe some of the latest findings in this area that seek to define the mechanisms of recruitment and control of activity of microtubule motors in spatial organization and cargo trafficking through the endosomal network.

  • References49
  • Citations21
  • References49
  • Citations21

Mentioned in this Paper

Golgi Apparatus
Motility Proteins
Kinesin Activity
Early Endosome
Trafficking
Microtubules
Sorting - Cell Movement
Rab GTP-Binding Proteins
Endosomes
Protein Isoforms

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