PMID: 9426363Jan 14, 1998Paper

The role of mouse intestinal microflora in the metabolism of trichloroethylene, an in vivo study

Human & Experimental Toxicology
A P MoghaddamJ C Lipscomb

Abstract

1. Both trichloroethylene and its metabolite, dichloroacetic acid, produce liver tumors peroxisome proliferation and other adverse cellular alterations in rodents. 2. The hepatic mechanism by which dichloroacetic acid is formed is not conclusively demonstrated, but pharmacokinetic models have successfully associated its formation with trichloroacetic acid as immediate precursor. 3. Previous investigations have shown that dichloroacetic acid is formed from trichloroacetic acid by gut microflora isolated in vitro. 4. To determine the impact of gut microflora on dichloroacetic acid formation from a trichloroethylene dose in vivo, we developed a procedure which reduced gut microflora some 3 orders of magnitude below published levels. 5. The administration of trichloroethylene to control mice and to mice whose gut was practically sterile resulted in equivalent concentrations of dichloroacetic acid and other metabolites in blood and liver, but significantly different content of these metabolites in cecum contents. 6. These data indicate that gut microflora contribute minimally, if at all, to the formation of circulating dichloroacetic acid under these conditions.

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Citations

Dec 3, 2003·Toxicology and Applied Pharmacology·Julian E A LeakeyWilliam T Allaben
Sep 13, 2006·Environmental Health Perspectives·Weihsueh A ChiuMarina V Evans
Dec 9, 2014·Mutation Research. Reviews in Mutation Research·Lawrence H LashIvan Rusyn
Nov 27, 1999·Drug Metabolism Reviews·K M GilbertN R Pumford
May 12, 2000·Environmental Health Perspectives·F Y Bois
May 12, 2000·Environmental Health Perspectives·L H LashJ C Parker

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