The role of mRNA translation in direct MHC class I antigen presentation

Current Opinion in Immunology
Sebastien ApcherRobin Fåhraeus

Abstract

It has been over 40 years since it was discovered that the major histocompatibility (MHC) class I molecules present peptides for the CD8 T cell-mediated immune response. The pathways for delivering and processing peptides for the MHC class I complexes have since been thoroughly studied but it is only until more recently that we start to understand the mechanisms that provide peptide material for the endogenous MHC class I pathway. Interestingly, the main source of antigenic peptide substrates does not come from the same mRNA translation mechanism that produces full length proteins but from ribosomes which products sole purpose might be to produce antigenic peptide substrates. We will discuss the latest development in this field and its implications for a better understanding of one of the corner stones for how the immune system distinguishes between self and non-self.

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Citations

Oct 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·Diego J Farfán-ArribasKenneth L Rock
Jan 10, 2013·Annual Review of Immunology·Janice S BlumPeter Cresswell
Feb 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Giora I MorozovDavid H Margulies
Sep 5, 2012·European Journal of Immunology·Benjamin M FiebigerJosef Mautner
Apr 23, 2016·Current Opinion in Immunology·Sébastien ApcherRobin Fåhraeus
Nov 23, 2017·Biology·Quinn H AbramBarbara A Katzenback
Feb 22, 2014·Disease Models & Mechanisms·Cécile VoissetMarc Blondel

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