The role of MT2-MMP in cancer progression

Biochemical and Biophysical Research Communications
Emiko ItoNariaki Matsuura

Abstract

The role of MT2-MMP in cancer progression remains to be elucidated in spite of many reports on MT1-MMP. Using a human fibrosarcoma cell, HT1080 and a human gastric cancer cell, TMK-1, endogenous expression of MT1-MMP or MT2-MMP was suppressed by siRNA induction to examine the influence of cancer progression in vitro and in vivo. In HT1080 cells, positive both in MT1-MMP and MT2-MMP, the migration as well as the invasion was impaired by MT1-MMP or MT2-MMP suppression. Also cell proliferation in three dimensional (3D) condition was inhibited by MT1-MMP or MT2-MMP suppression and tumor growth in the nude mice transplanted with tumor cells were reduced either MT1-MMP or MT2-MMP suppression with a prolongation of survival time in vivo. MT2-MMP suppression induces more inhibitory effects on 3D proliferation and in vivo tumor growth than MT1-MMP. On the other hand, TMK-1 cells, negative in MT1-MMP and MMP-2 but positive in MT2-MMP, all the migratory, invasive, and 3D proliferative activities in TMK-1 are decreased only by MT2-MMP suppression. These results indicate MT2-MMP might be involved in the cancer progression more than or equal to MT1-MMP independently of MMP-2 and MT1-MMP.

References

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Citations

Sep 25, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Magdalena BodnarAndrzej Marszalek
May 6, 2014·Biochimica Et Biophysica Acta·Maria-Ioanna EllinaNikos K Karamanos
Jul 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmet ÖzdemirFatih Demirci
Jul 5, 2016·Oncotarget·Yusi LiuLingyun Zhou
Dec 31, 2019·Analytical Cellular Pathology (Amsterdam)·Cristian ScheauMonica Neagu
Dec 11, 2019·The Journal of Cell Biology·Priyanka SharmaSunando Datta
Jun 27, 2020·Cancer Cell International·Xiao JinZheng Liu

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