The role of mTOR in ovarian Neoplasms, polycystic ovary syndrome, and ovarian aging

Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists
Jin LiuMei-Xiang Li

Abstract

The mammalian target of rapamycin, mTOR, is a serine-threonine protein kinase downstream of the phosphatidylinositol 3-kinase (PI3K)-AKT axis. The pathway can regulate cell growth, proliferation, and survival by activating ribosomal kinases. Recent studies have implicated the mTOR signaling pathway in ovarian neoplasms, polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Preclinical investigations have demonstrated that the PI3K/AKT/mTOR pathway is frequently activated in the control of various ovarian functions. mTOR allows cancer cells to escape the normal biochemical system and regulates the balance between apoptosis and survival. Some recent studies have suggested that involvement of the mTOR signaling system is an important pathophysiological basis of PCOS. Overexpression of the mTOR pathway can impair the interaction of cumulus cells, lead to insulin resistance, and affect the growth of follicles directly. The roles of mTOR signaling in follicular development have been extensively studied in recent years; abnormalities in this process lead to a series of pathologies such as POF and infertility. To improve understanding of the role of the mTOR signaling pathway in the pathogenesis and development of ovari...Continue Reading

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Jul 25, 2019·Anatomy & Cell Biology·Mohammad-Amin AbdollahifarShabnam Abdi
Dec 29, 2020·Pediatric Blood & Cancer·Paloma Triana, Juan Carlos López-Gutierrez
Jun 9, 2021·Expert Opinion on Therapeutic Patents·Han-Yue QiuMin Zhang
Jul 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Liyun DuanFengmei Lian
Aug 17, 2021·Journal of Clinical Laboratory Analysis·Vahid SaeediMaryam Razzaghy-Azar

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