The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles

Materials
Iwona Inkielewicz-StepniakMaria Jose Santos-Martinez

Abstract

The development of novel oral drug delivery systems is an expanding area of research and both new approaches for improving their efficacy and the investigation of their potential toxicological effect are crucial and should be performed in parallel. Polystyrene nanoparticles (NPs) have been used for the production of diagnostic and therapeutic nanosystems, are widely used in food packaging, and have also served as models for investigating NPs interactions with biological systems. The mucous gel layer that covers the epithelium of the gastrointestinal system is a complex barrier-exchange system that it is mainly constituted by mucin and it constitutes the first physical barrier encountered after ingestion. In this study, we aimed to investigate the effect of polystyrene NPs on mucin and its potential role during NP⁻cell interactions. For this purpose, we evaluated the interaction of polystyrene NPs with mucin in dispersion by dynamic light scattering and with a deposited layer of mucin using a quartz crystal microbalance with dissipation technology. Next, we measured cell viability and the apoptotic state of three enterocyte-like cell lines that differ in their ability to produce mucin, after their exposure to the NPs. Positive c...Continue Reading

References

Jun 6, 2000·Advanced Drug Delivery Reviews·D A NorrisP J Sinko
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AtumaL Holm
Apr 1, 2004·Journal of Agricultural and Food Chemistry·Jorge E Loyo-RosalesAlba Torrents
Mar 16, 2005·Lancet·Anthony Seaton, Kenneth Donaldson
Jun 7, 2005·Molecular Pharmaceutics·Anna Maria CalcagnoJoseph A Ware
Oct 24, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Siwar Chayed, Françoise M Winnik
Jun 24, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Karen TiedeMartin Hassellov
Jan 13, 2009·Advanced Drug Delivery Reviews·Richard A Cone
Jan 27, 2009·Advanced Drug Delivery Reviews·Samuel K LaiJustin Hanes
Mar 21, 2009·Bioorganic & Medicinal Chemistry·Amir H Faraji, Peter Wipf
Nov 19, 2010·PloS One·Eric Y T ChenWei-Chun Chin
Mar 2, 2011·Environmental Health Perspectives·Rebecca Kessler
Mar 12, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia Resta-LenertSamuel B Ho
Aug 16, 2011·Critical Reviews in Food Science and Nutrition·Ladan Rashidi, Kianoush Khosravi-Darani
Jan 26, 2012·International Journal of Nanomedicine·Maria Jose Santos-MartinezMarek Witold Radomski
Feb 12, 2015·Beilstein Journal of Nanotechnology·Cornelia LoosThomas Simmet
Aug 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sejin OhSalvador Borrós
Jun 14, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abhijit A DateLaura M Ensign
Oct 4, 2017·Advanced Drug Delivery Reviews·Rama Bansil, Bradley S Turner

❮ Previous
Next ❯

Citations

Feb 20, 2020·International Journal of Environmental Research and Public Health·Claudia CampanaleVito Felice Uricchio
Sep 12, 2019·International Journal of Environmental Research and Public Health·Suhee Kim, Ju-Yeon Uhm
Jan 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Frederikke Emilie Heddagaard, Peter Møller
Feb 1, 2021·Journal of Hazardous Materials·Manish KumarMohammad J Taherzadeh
Dec 15, 2020·The Science of the Total Environment·Arifur RahmanJaroslav Slobodnik
Mar 7, 2021·Nanomaterials·Maxine Swee-Li YeeChee-Onn Leong
Mar 28, 2021·The Science of the Total Environment·Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez-Oliván
Apr 25, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sara MatthewsElvis Genbo Xu
Jan 11, 2019·Environmental Science & Technology·Roman LehnerBarbara Rothen-Rutishauser

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic light scattering
Quartz
Quartz Crystal Microbalance
optical microscopy
QCM-D
flow cytometry

Software Mentioned

QCM
QSoft401
GraphPad
QTools
Origin
GraphPad Prism

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Birgit J TeublEva Roblegg
Methods in Molecular Biology
A Allen, J P Pearson
© 2022 Meta ULC. All rights reserved