PMID: 9439153Jun 1, 1997Paper

The role of mucosal biopsy in the diagnosis of chronic diarrhea: value of multiple biopsies when colonoscopic finding is normal or nonspecific

The Korean Journal of Internal Medicine
J H LeeJ C Rhee

Abstract

There are controversies about taking routine mucosal biopsy when the gross colonoscopic finding is normal. This study was conducted to determine the frequency of clinically important histological abnormalities, prospectively, in chronic diarrhea patients with grossly normal or nonspecific colonoscopic findings. One hundred and eighteen patients suffering from nonbloody diarrhea with average frequency of more than two times a day for more than 4 weeks were included. Multiple biopsies (cecum, ascending colon, mid-transverse colon, descending colon, sigmoid colon and rectum) were taken during colonoscopic examinations and each biopsy specimen was reviewed by one pathologist after H&E and Masson-trichrome staining. Clinically significant abnormalities (2 collagenous colitis, 1 lymphocytic colitis, 1 eosinophilic enterocolitis, 1 ulcerative colitis and 4 melanosis coli) were observed in 9 patients (7.6%). Sixteen cases (13.6%) of borderline histological abnormalities were observed (8 cases of possible collagenous colitis and 8 cases showing some features of lymphocytic colitis). Ninety two cases (78.8%) showed nonspecific inflammation only. Clinically important histological lesions can exist in significant percentage in spite of nor...Continue Reading

References

Jun 1, 1991·Digestive Diseases and Sciences·D A Stampfl, L S Friedman
Jan 1, 1987·Annals of Internal Medicine·H RamsL Ghandur-Mnaymneh
Jul 1, 1987·Digestive Diseases and Sciences·A PriorP J Whorwell
Aug 1, 1987·Mayo Clinic Proceedings·K K WangW J Tremaine
May 1, 1986·Gut·J G KinghamA M Dawson
Mar 1, 1986·Archives of Disease in Childhood·I R SandersonJ A Walker-Smith
May 1, 1985·The Journal of Clinical Investigation·G W Bo-LinnJ S Fordtran
Jun 1, 1985·Journal of Pediatric Gastroenterology and Nutrition·D J Unsworth, J A Walker-Smith
Dec 28, 1972·The New England Journal of Medicine·B C Morson
Dec 4, 1982·British Medical Journal·J G KinghamA M Dawson
Mar 16, 1995·The New England Journal of Medicine·M DonowitzR Saidi

❮ Previous
Next ❯

Citations

Jul 14, 2012·ISRN Gastroenterology·Mahreema JawairiaPaul Mustacchia
Mar 30, 2010·Gastrointestinal Endoscopy·Bo ShenJason A Dominitz
Sep 18, 2007·Immunology and Allergy Clinics of North America·Li Zuo, Marc E Rothenberg
Jul 14, 2010·Journal of Gastroenterology and Hepatology·Takuya InoueKazuhide Higuchi
Apr 14, 2016·The American Journal of Gastroenterology·Mark S RiddleBradley A Connor
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Marc E Rothenberg
Jun 19, 2004·Digestion·Marcella MüllerPer-Ove Stotzer
May 2, 2002·Journal of Gastroenterology and Hepatology·Ian F YusoffNeville E Hoffman
Jul 16, 1999·The American Journal of Gastroenterology·A TrommA Fisseler-Eckhoff
Dec 13, 2005·Journal of Clinical Gastroenterology·José Guilherme Nogueira da SilvaAytan Miranda Sipahi
Jan 18, 2006·Digestive Diseases and Sciences·Maribel Rodríguez-TorresAcisclo M Marxuach-Cuétara
Jun 19, 2012·Journal of Crohn's & Colitis·A MünchUNKNOWN European Microscopic Colitis Group (EMCG)
Oct 22, 2008·Scandinavian Journal of Gastroenterology·Anders LassonPer-Ove Stotzer
May 2, 2002·Journal of Gastroenterology and Hepatology·Peter TagkalidisPeter Gibson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
S De La RivaM A Muñoz Navas
Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
A HajiS Papagrigoriadis
© 2021 Meta ULC. All rights reserved