The role of multifilament structures and lateral interactions in dynamics of cytoskeleton proteins and assemblies

The Journal of Physical Chemistry. B
Xin Li, Anatoly B Kolomeisky

Abstract

Microtubules and actin filaments are biopolymer molecules that are major components of cytoskeleton networks in biological cells. They play important roles in supporting fundamental cellular processes such as cell division, signaling, locomotion, and intracellular transport. In cells, cytoskeleton proteins function under nonequilibrium conditions that are powered by hydrolysis of adenosine triphosphate (ATP) or guanosine triphosphate (GTP) molecules attached to them. Although these biopolymers are critically important for all cellular processes, the mechanisms that govern their complex dynamics and force generation remain not well explained. One of the most difficult fundamental issues is to understand how different components of cytoskeleton proteins interact together. We develop an approximate theoretical approach for analyzing complex processes in cytoskeleton proteins that takes into account the multifilament structure, lateral interactions between parallel protofilaments, and the most relevant biochemical transitions during the biopolymer growth. It allows us to fully evaluate collective dynamic properties of cytoskeleton filaments as well as the effect of external forces on them. It is found that for the case of strong la...Continue Reading

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Citations

Oct 17, 2015·The Journal of Chemical Physics·Carlo PierleoniJean-Paul Ryckaert
Feb 8, 2018·Scientific Reports·Jemseena Valiyakath, Manoj Gopalakrishnan
Nov 29, 2017·Physical Chemistry Chemical Physics : PCCP·Zi He, Kunkun Guo
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Feb 17, 2019·The European Physical Journal. E, Soft Matter·Raj Kumar Sadhu, Sakuntala Chatterjee

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