The Role of MYCN in Symmetric vs. Asymmetric Cell Division of Human Neuroblastoma Cells

Frontiers in Oncology
Hideki IzumiAkira Nakagawara

Abstract

Asymmetric cell division (ACD) is an important physiological event in the development of various organisms and maintenance of tissue homeostasis. ACD produces two different cells in a single cell division: a stem/progenitor cell and differentiated cell. Although the balance between self-renewal and differentiation is precisely controlled, disruptions to ACD and/or enhancements in the self-renewal division (symmetric cell division: SCD) of stem cells resulted in the formation of tumors in Drosophila neuroblasts. ACD is now regarded as one of the characteristics of human cancer stem cells, and is a driving force for cancer cell heterogeneity. We recently reported that MYCN controls the balance between SCD and ACD in human neuroblastoma cells. In this mini-review, we discuss the mechanisms underlying MYCN-mediated cell division fate.

References

Mar 4, 2003·Nature Reviews. Cancer·Garrett M Brodeur
Sep 6, 2005·Nature Genetics·Emmanuel Caussinus, Cayetano Gonzalez
Sep 17, 2005·Cancer Research·Giuseppe GianniniAlberto Gulino
Jun 27, 2006·Nature Cell Biology·Vasily ShininShahragim Tajbakhsh
Jul 1, 2006·Nature·Sean J Morrison, Judith Kimble
Jul 15, 2006·Seminars in Cancer Biology·Robert A Ross, Barbara A Spengler
Dec 22, 2006·Genes & Development·Hongyan WangWilliam Chia
Jan 27, 2007·Science·Yukiko M YamashitaMargaret T Fuller
Jan 4, 2008·Nature·Ivan N ColalucaPier Paolo Di Fiore
Mar 18, 2008·Cell Stem Cell·Mingfu WuTannishtha Reya
Apr 24, 2008·Nature Reviews. Molecular Cell Biology·Pierre Gönczy
Oct 14, 2010·Biochimica Et Biophysica Acta·Salvatore PecePier Paolo Di Fiore
Dec 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sandra AckermannMatthias Fischer
Oct 9, 2012·Nature Genetics·Jan J MolenaarJohannes H Schulte
Oct 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hideki Izumi, Yasuhiko Kaneko
Nov 13, 2012·Current Topics in Developmental Biology·Hitoshi Sawa
Sep 21, 2013·Nature·Corbin E Meacham, Sean J Morrison
Oct 3, 2013·Cold Spring Harbor Perspectives in Medicine·Miller Huang, William A Weiss
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Omid F Harandi, Victor R Ambros
Oct 21, 2015·Cancer Cell·Robert W SchneppSharon J Diskin
Oct 1, 2014·Molecular & Cellular Oncology·Hideki Izumi, Yasuhiko Kaneko
Nov 11, 2016·Nature Reviews. Disease Primers·Katherine K MatthayWilliam A Weiss
Jan 30, 2018·Japanese Journal of Clinical Oncology·Akira NakagawaraMasanori Nishi
Jul 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Laura KerosuoMarianne E Bronner
Feb 23, 2020·Science Translational Medicine·Yu-Feng GuoShi-Cang Yu

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Citations

Feb 23, 2021·Frontiers in Oncology·Ruochen LiuHongjuan Cui

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Methods Mentioned

BETA
ubiquitination

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