The role of N-acetylcysteine in the prevention of contrast-induced nephrotoxicity

Cardiovascular and Interventional Radiology
Caron SandhuDavid B Oliveira

Abstract

To determine the role of prophylactic N-acetylcysteine in the prevention of contrast-induced nephrotoxicity. One hundred and sixteen patients undergoing noncoronary angiography, with or without pre-existing renal impairment, were randomly assigned to receive prophylactic oral N-acetylcysteine or no treatment. Serum creatinine (sCr) was measured prior to angiography and 48 hr after the procedure. Urine samples were collected before and after the examination for measurement of malondialdehyde (MDA) concentration. Contrast-induced nephrotoxicity (CIN) was defined as a rise in serum creatinine of 0.5 mg/dl (44 mmol/l) at 48 hr. Complete data were available on 106 patients, 53 of whom had received N-acetylcysteine. There were no significant differences between the two groups in baseline characteristics, type of angiogram, or volume and concentration of contrast used. Three patients (2.8%), all of whom had received N-acetylcysteine, developed CIN. In the N-acetylcysteine group, the mean serum creatinine in patients with renal impairment was 151.0 +/- 44.2 micromol/l prior to the procedure and 155.6 +/- 48.6 micromol/l (p = 0.49) after the procedure. Respective values for those without renal impairment were 79.6 +/- 15.1 micromol/l an...Continue Reading

References

Jul 1, 1991·AJR. American Journal of Roentgenology·E M LautinS Sprayregen
Jul 1, 1991·AJR. American Journal of Roentgenology·M A Bettmann
Jan 1, 1990·The American Journal of Physiology·M B Grisham, E M Ryan
Nov 1, 1990·The American Journal of Medicine·C L ManskeY Wang
Sep 1, 1969·Investigative Radiology·T Sherwood, J P Lavender
Nov 1, 1983·AJR. American Journal of Roentgenology·S T CochranD J Roe
Jan 7, 2000·The British Journal of Radiology·N Chalmers, R W Jackson
Jul 20, 2000·The New England Journal of Medicine·M TepelW Zidek
Jan 26, 2002·The American Journal of Cardiology·Larry J Diaz-SandovalDouglas W Losordo
Jul 11, 2002·Journal of the American College of Cardiology·Carlo BriguoriBruno Ricciardelli
Aug 22, 2002·Academic Radiology·C SandhuD Oliveira
Oct 24, 2002·Journal of the American College of Cardiology·Kou Gi ShyuPeiliang Kuan
Nov 1, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Suhail AllaqabandTanvir K Bajwa
Feb 7, 2003·The New England Journal of Medicine·Peter AspelinUNKNOWN Nephrotoxicity in High-Risk Patients Study of Iso-Osmolar and Low-Osmolar Non-Ionic Contrast Media Study Investigators
Aug 29, 2003·Lancet·Rainer BirckClaude Braun
Jan 9, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alvaro AlonsoMark J Sarnak
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Abhijit V KshirsagarWilliam F Finn
Apr 17, 2004·Kidney International·Neesh PannuMarcello Tonelli
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeffrey W H FungJohn E Sanderson
May 7, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luciano F DragerAntonio Carlos Seguro
Jun 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Arif Asif, Murray Epstein
Jan 5, 2005·The American Journal of Medicine·Brahmajee K NallamothuEric R Bates

❮ Previous
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Citations

Jul 14, 2010·Current Opinion in Nephrology and Hypertension·Steven D Weisbord, Paul M Palevsky
Oct 14, 2006·BMJ : British Medical Journal·Rachel Hilton
Mar 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Paul M PalevskySteven D Weisbord
Jul 26, 2011·Seminars in Nephrology·Steven D Weisbord, Paul M Palevsky
Mar 8, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Anand PrasadDavid M Kaye
Apr 18, 2016·Seminars in Nephrology·Steven D Weisbord, Paul M Palevsky
Aug 28, 2016·British Journal of Anaesthesia·G T C WongM G Irwin
Feb 26, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Stella S DaskalopoulouGeorge Geroulakos
Dec 3, 2009·Critical Pathways in Cardiology·Troy E MadsenUNKNOWN Intermountain Heart Collaborative (IHC) Study Group
Aug 10, 2007·Journal of the American Society of Nephrology : JASN·Anja Sachse, Gunter Wolf
May 11, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Steven D WeisbordPaul M Palevsky
Feb 13, 2007·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Stewart R WalshJonathan R Boyle
Apr 15, 2010·Journal of Clinical Pharmacology·Burhan OzdilMacit Sandikci
May 4, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Saad S GhummanAnand Prasad
May 7, 2020·Diagnostics·Zbigniew KrasinskiKrzysztof Pawlaczyk
Jun 14, 2006·Gan to kagaku ryoho. Cancer & chemotherapy·Hidetaka SumiyoshiKeiko Fukuhara
Jan 4, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Fatih AksoyHasan Basri Savaş

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