During the last decade, considerable progress was made in the understanding of the natural killer (NK) cell mechanisms of action, especially in the processes of target cell recognition and lysis. These breakthroughs have aroused large interest in the role of NK cells in the pathogenesis of a variety of diseases. In hematopoietic stem cell transplantation, NK cells have been shown to play a significant role in the graft-versus-leukemic effect leading to protocols of cell therapy using amplified NK cells after transplantation. In human solid organ transplantation (SOT), the role of NK cells was controversial due to conflicting clinical and animal model data. NK cells have been shown to exacerbate T-cell responses during rejection, but also to promote tolerance induction under immunosuppression. The role of NK cells is of special interest in SOT because in contrast to T cells, the effect of immunosuppressive drugs on NK cells is modest, at least in vivo. Recent publications demonstrated the importance of killer cell immunoglobulin-like receptor/human leukocyte antigen genotypes to predict the risk of rejection and to prevent cytomegalovirus infection/reactivation. NK cell subpopulations could have different alloreactivity or immun...Continue Reading
Effect of FK506 versus cyclosporine on human natural and antibody-dependent cytotoxicity reactions in vitro
Effect of in vitro cyclosporin. A treatment on human natural and antibody-dependent cell-mediated cytotoxicity
Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors.
Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation
Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.
NK cells can trigger allograft vasculopathy: the role of hybrid resistance in solid organ allografts
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner
Tacrolimus/mycophenolate mofetil improved natural killer lymphocyte reconstitution one year after kidney transplant by reference to cyclosporine/azathioprine
Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors
Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic HCV patients
The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations
The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors
Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation
Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells
Lack of killer immunoglobulin-like receptor 2DS2 (KIR2DS2) and KIR2DL2 is associated with poor responses to therapy of recurrent hepatitis C virus in liver transplant recipients
Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation
NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection
Natural killer cell receptor--repertoire and functions after induction therapy by polyclonal rabbit anti-thymocyte globulin in unsensitized kidney transplant recipients
Rapamycin and MPA, but not CsA, impair human NK cell cytotoxicity due to differential effects on NK cell phenotype
Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?
Expression of killer cell immunoglobulin-like receptors (KIRs) by natural killer cells during acute CMV infection after kidney transplantation
Epigenetics in Kidney Transplantation: Current Evidence, Predictions, and Future Research Directions
Acute-phase protein α1-anti-trypsin: diverting injurious innate and adaptive immune responses from non-authentic threats
The association between killer-cell immunoglobulin-like receptor (KIR) and KIR ligand genotypes and the likelihood of BK virus replication after kidney transplantation
CCL21-expression and accumulation of CCR7+ NK cells in livers of patients with primary sclerosing cholangitis
Natural Killer Cells Exhibit an Activated Phenotype in Peripheral Blood Mononuclear Cells of Renal Allograft Rejection Recipients: A Preliminary Study
KIR gene mismatching and KIR/C ligands in liver transplantation: consequences for short-term liver allograft injury
Unveiling the Role of DNA Methylation in Kidney Transplantation: Novel Perspectives toward Biomarker Identification
Recombinant expression, in vitro refolding and characterizing disulfide bonds of a mouse inhibitory C-type lectin-like receptor Nkrp1b
Dissecting the Multiplicity of Immune Effects of Immunosuppressive Drugs to Better Predict the Risk of de novo Malignancies in Solid Organ Transplant Patients
A Retrospective Study on Human Leukocyte Antigen Types and Haplotypes in a South African Population.
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