The role of natural killer cells in the induction of autoimmune gastritis

Autoimmunity
N L La GrutaP A Gleeson

Abstract

A number of experimental models of organ-specific autoimmunity involve a period of peripheral T cell lymphopenia prior to disease onset. In particular, experimental autoimmune gastritis, induced in susceptible mouse strains by neonatal thymectomy, is a CD4+ T cell mediated autoimmune disease. We have previously demonstrated that this disease displays the hallmarks of a Th1-mediated DTH inflammatory response with an essential role for IFN-gamma very early in the pathogenesis of disease. Given the interplay between the innate and adaptive immune responses, a potential source of early IFN-gamma production in these lymphopenic mice is the innate immune response. Here we have assessed the contribution of innate immunity to the induction of experimental autoimmune gastritis, in particular, the role of natural killer (NK) cells in production of IFN-gamma. Analysis of NK cells and macrophages revealed no difference in either the number or activation status between euthymic and neonatally thymectomised mice. Furthermore, in vivo depletion of NK cells immediately after neonatal thymectomy of (BALB/cCrSlcxC57BL/6) F1 mice demonstrated no reduction in disease incidence compared to control groups of neonatally thymectomised mice. Therefore,...Continue Reading

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Citations

Jul 10, 2003·Autoimmunity Reviews·Ian R van DrielPaul A Gleeson
Mar 15, 2005·International Reviews of Immunology·J FieldB-H Toh
May 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lisa LitFrank R Sharp
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Dagmar von BubnoffJacques Zimmer
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magali TermeLaurence Zitvogel

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