The role of neoadjuvant imatinib mesylate therapy in sphincter-preserving procedures for anorectal gastrointestinal stromal tumor

American Journal of Clinical Oncology
Jian-Ping WangXiao-Jian Wu

Abstract

To explore the role of neoadjuvant imatinib mesylate (IM) therapy in sphincter-preserving procedures for anorectal gastrointestinal stromal tumor (GIST). Between January and December of 2007, 3 patients with primary anorectal GIST who declined recommendations to receive abdominoperineal resection of the rectum, were treated with IM at a single institution. Tumor size, distance to anal edge, and the number of mitoses were compared before and after the treatment. After 12 weeks of IM therapy, conservative surgical procedures were performed. After IM therapy for the 3 patients, computed tomography scan, colonoscopy, and biopsy showed a decrease in size of the rectal mass, an extension in the distance to anal edge, and a reduction in mitotic count. During this treatment regimen, the patients did not experience any side effects. A sphincter-preserving transsacral excision with direct coloanal anastomosis was performed and the resection margins were uninvolved on all sides. During 22 to 28 months postoperatively, the function of anal sphincter was satisfactory and no recurrence occurred among all 3 patients. Neoadjuvant IM therapy for anorectal GIST is safe and effective. Tumor shrinkage and an extension of the distance to anal edge ...Continue Reading

References

Jun 1, 1986·Diseases of the Colon and Rectum·A A KhalifaM J Williams
Sep 1, 1983·The American Journal of Surgical Pathology·M T Mazur, H B Clark
Aug 6, 1999·The American Journal of Surgical Pathology·J A TworekH D Appelman
Oct 18, 2000·Annals of Surgical Oncology·I PidhoreckyJ F Gibbs
Feb 24, 2001·European Radiology·Y HamaS Kusano
Apr 11, 2001·European Journal of Gastroenterology & Hepatology·Y ShibataN Yagihashi
Nov 14, 2001·Lancet·A T van OosteromUNKNOWN European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Sep 30, 2003·The British Journal of Surgery·E M ConnollyJ V Reynolds
May 5, 2004·Annals of Surgical Oncology·Burton L Eisenberg, Ian Judson
Mar 29, 2005·Diseases of the Colon and Rectum·Shelly S LoRamesh K Ramanathan
Apr 7, 2005·Gastrointestinal Endoscopy·Janak N ShahGregory G Ginsberg
Feb 1, 2007·Annals of Surgical Oncology·Jason S Gold, Ronald P Dematteo
May 13, 2009·The British Journal of Surgery·P GervazP Morel

❮ Previous
Next ❯

Citations

Sep 4, 2012·Clinics in Colon and Rectal Surgery·Dimitra G Theodoropoulos
Mar 19, 2014·Cirugía española·José Errasti AlustizaAngel Reina Duarte
Jan 31, 2013·Techniques in Coloproctology·D CentonzeG Giannone
Nov 29, 2011·Current Problems in Cancer·Rashmi Chugh
Apr 11, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Caio Sergio Rizkallah NahasIvan Cecconello
Apr 20, 2017·Surgery Today·Masayoshi YasuiUNKNOWN Kinki GIST Study Group
Oct 4, 2012·Expert Review of Anticancer Therapy·Brian K BednarskiKelly K Hunt
Aug 8, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hamda AlmaazmiChady Atallah
Nov 18, 2018·Surgery Today·Manabu KanekoHiroaki Nozawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.