The role of neural stem cells for in vitro models of schizophrenia: neuroprotection via Akt/ERK signal regulation

Schizophrenia Research
Takafumi OnoToshikazu Saito

Abstract

Recent neuroimaging studies have revealed progressive morphological brain changes during the course of schizophrenia, and the neurotrophic and neurogenetic effects of atypical antipsychotics are believed to prevent or retard these brain volume reductions. In addition to drug-induced neural stem cell (NSC) activation, transplantation of exogenous NSCs has been proposed as a possible approach to repair the damaged brain in psychiatric disease. NSC transplantation embraces not only neuron replacement but also enhanced neuroprotection of existing neurons with the goal of restoring the impaired brain. However, little is known about the cell-cell interactions of exogenous NSCs with existing neurons, or about their neuroprotective actions especially in psychiatric diseases. In the present study, we used cortical neuron cultures to examine the neurotrophism and neuroprotection of exogenous NSCs against the neuronal damage induced by exposure to the NMDA receptor antagonist, MK-801. We also investigated their role in serum/nutrient deprivation stress. The exogenous NSCs exerted neuroprotective effects against both types of apoptotic injuries considered as in vitro schizophrenic disease models. Exogenous NSCs also altered cellular surviv...Continue Reading

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Citations

May 29, 2012·Critical Care Medicine·Chaoxuan DongK J S Anand
May 26, 2012·Psychiatry and Clinical Neurosciences·Rodrigo Barbachan MansurElisa Brietzke
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Grazia PerroneAntonio Scilimati

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