The Role of Neurohypophyseal Hormones Vasopressin and Oxytocin in Neuropsychiatric Disorders

Endocrine, Metabolic & Immune Disorders Drug Targets
Michele IovinoVincenzo Triggiani

Abstract

Although the neurohypophyseal hormones vasopressin (VP) and oxytocin (OT) are mostly known for their role respectively in antidiuresis, and in labour, lactation and maternal behavior, both might exert widespread influences either on emotion and cognition in healthy subjects, showing some gender-related differences. They interact with each other facilitating shifts between positive socially- oriented and defensive states. In fact, VP amplifies the reactivity to stressors showing also beneficial effects on attention, verbal learning as well as memory, whereas OT reduces the amplitude of the stress response, improves emotion processing, and can play a negative effect on memory and verbal learning in healthy individuals. Several data indicate the possible involvement of these neuropeptides in the pathophysiology of psychiatric conditions involving social interactions, such as autism, as well as in schizophrenia and depression. The aim of this paper is to review the literature relating to the role played by neurohypophyseal hormones in neuropsychiatric disorders. We analyzed the best of published literature dealing with the relationships between neurohypophyseal hormones and neuropsychiatric conditions like autism (AD), major depres...Continue Reading

Citations

Apr 19, 2018·International Review of Psychiatry·James Harris
Nov 30, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Bo XiangJoel Gelernter
Mar 19, 2019·The Journal of Clinical Endocrinology and Metabolism·Anna AulinasElizabeth A Lawson
Feb 2, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Michele IovinoVincenzo Triggiani
Jul 25, 2019·Journal of Clinical Medicine·Mohamed A HendausAhmed H Alhammadi
Dec 3, 2020·International Journal of Molecular Sciences·Olivia J VeatchJason H Moore
Mar 3, 2021·International Review of Psychiatry·Bethany OakleyDeclan G Murphy
May 21, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Michele IovinoVincenzo Triggiani

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