PMID: 11328454May 1, 2001Paper

The role of neuropeptide Y in orexin-induced hypothalamic-pituitary-adrenal activation

Journal of Neuroendocrinology
Miklós JászberényiGyula Telegdy

Abstract

The role of neuropeptide Y (NPY) in the mediation of orexin-induced hypothalamic-pituitary-adrenal (HPA) activation was investigated in the rat. The HPA system was stimulated by intracerebroventricular (i.c.v.) administration of orexin-A or orexin-B (140 or 280 pmol, respectively) and the plasma concentration of corticosterone was used as an index of the degree of activation. i.c.v. pretreatment with NPY antagonist or NPY antiserum (30 min or 24 h before orexin administration, respectively) inhibited the orexin-induced corticosterone release. The inhibitory actions of the antagonist and the antiserum were revealed by the dose-response curve; the highest concentrations practically abolished the HPA activation evoked by the orexins. These data suggest that the HPA system-stimulating effect of the orexins may be mediated by NPY.

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Citations

Feb 7, 2002·Regulatory Peptides·Miklós JászberényiGyula Telegdy
Jul 2, 2003·Regulatory Peptides·Kiyoshi MatsumuraMitsuo Iida
Apr 3, 2002·Brain Research Bulletin·Yingzi LinMitsuo Iida
Feb 22, 2002·European Journal of Biochemistry·Heike A WielandAnnette G Beck-Sickinger
Jun 8, 2002·Annual Review of Neuroscience·Shahrad TaheriEmmanuel Mignot
Aug 6, 2009·Frontiers in Neuroendocrinology·Miguel LópezCarlos Diéguez
Dec 31, 2008·Neurochemistry International·Ikuko KodomariKeiji Wada
Oct 10, 2013·British Journal of Pharmacology·Jingcheng LiLuis de Lecea
Jun 17, 2014·Behavioural Brain Research·Miklós PalotaiMiklós Jászberényi
Mar 5, 2011·The Journal of Medical Investigation : JMI·Machiko KiyokawaMinoru Irahara
Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·Greti Aguilera
Aug 30, 2011·Frontiers in Neuroendocrinology·Greti Aguilera, Ying Liu
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Nicolas Rohleder, Clemens Kirschbaum
Nov 7, 2002·American Journal of Physiology. Cell Physiology·Jyrki P KukkonenKarl E O Akerman
Mar 2, 2006·Pharmacological Reviews·Raffaella SpinazziGastone G Nussdorfer
Nov 12, 2003·Experimental Biology and Medicine·Yoichi UetaTatsushi Onaka
Dec 14, 2018·Frontiers in Neuroscience·Mei-Fang LiuLei Chen
May 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allen S LevineLuis de Lecea

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