The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease

Journal of Neuroinflammation
Amanda J StockH Anne Pereira

Abstract

Neutrophils are the innate immune system's first line of defense. Neutrophils play a critical role in protecting the host against infectious pathogens, resolving sterile injuries, and mediating inflammatory responses. The granules of neutrophils and their constituent proteins are central to these functions. Although neutrophils may exert a protective role upon acute inflammatory conditions or insults, continued activity of neutrophils in chronic inflammatory diseases can contribute to tissue damage. Neutrophil granule proteins are involved in a number of chronic inflammatory conditions and diseases. However, the functions of these proteins in neuroinflammation and chronic neuroinflammatory diseases, including Alzheimer's disease (AD), remain to be elucidated. In this review, we discuss recent findings from our lab and others that suggest possible functions for neutrophils and the neutrophil granule proteins, CAP37, neutrophil elastase, and cathepsin G, in neuroinflammation, with an emphasis on AD. These findings reveal that neutrophil granule proteins may exert both neuroprotective and neurotoxic effects. Further research should determine whether neutrophil granule proteins are valid targets for therapeutic interventions in chr...Continue Reading

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Citations

Mar 12, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Dana M TilleyRicardo Vallejo
Apr 17, 2020·Investigative Ophthalmology & Visual Science·Anne Kasus-JacobiH Anne Pereira
Jun 4, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E V ProskurninaA N Khannanova
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Feb 26, 2021·Reproductive Biology and Endocrinology : RB&E·Ga-Hyun SonSung Taek Park
Apr 4, 2021·Physiology & Behavior·Suparna Roy SarkarSugato Banerjee
Oct 16, 2020·Nutritional Neuroscience·J B Senthil Kumar, Bhawna Sharma
Jul 25, 2021·International Journal of Molecular Sciences·Namdoo Kim, Hyuck Jin Lee
Aug 1, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shuo WangYihui Deng
Dec 18, 2021·Frontiers in Aging Neuroscience·Jaime Ramos-CejudoRicardo S Osorio
Aug 26, 2021·Current Alzheimer Research·Anne Kasus-JacobiHeloise Anne Pereira
Jul 13, 2019·Environmental Research·Lilian Calderón-GarcidueñasAngélica González-Maciel

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