The Role of Neutrophilic Inflammation, Angiotropism, and Pericytic Mimicry in Melanoma Progression and Metastasis

The Journal of Investigative Dermatology
Jennifer LandsbergClaire Lugassy

Abstract

Angiotropism in melanoma correlates with ulceration and poor prognosis. It has been shown to be a marker of pericytic mimicry, that is, the spreading of tumor cells in a pericyte location along abluminal vascular surfaces. Such extravascular tumor spread may represent another form of tumor plasticity with reversion to a neural crest cell migratory phenotype. In a murine melanoma model, it has recently been demonstrated that neutrophilic skin inflammation promotes angiotropism and metastatic spread of primary melanomas. This review discusses the role of neutrophilic inflammation in angiotropism and pericytic mimicry in melanoma progression, metastasis, tumor cell plasticity, and tumor therapeutic resistance.

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Citations

Dec 20, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Andrea P MoyStefan Kraft
Feb 28, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Raymond L BarnhillClaire Lugassy
Feb 15, 2017·The FEBS Journal·Imanol Arozarena, Claudia Wellbrock
Jul 6, 2017·International Journal of Cancer. Journal International Du Cancer·Yu KouLinlin Lu
Aug 14, 2018·The Journal of Pathology·Victor Ljl ThijssenArjan W Griffioen
Apr 17, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·A NirenbergA Dixon
Nov 22, 2018·Frontiers in Medicine·Robert J JuNikolas K Haass
Jan 19, 2021·Revista española de patología : publicación oficial de la Sociedad Española de Anatomía Patológica y de la Sociedad Española de Citología·Antonio Tejera-VaquerizoJosé Luis Rodríguez-Peralto

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