The role of next generation sequencing in infection prevention in human parainfluenza virus 3 infections in immunocompromised patients.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Atul KothariDarrell L Dinwiddie

Abstract

Respiratory viral infections are a significant problem in patients with hematologic malignancies. We report a cluster of HPIV 3 infections in our myeloma patients, and describe the utility of next generation sequencing (NGS) to identify transmission linkages which can assist in infection prevention. To evaluate the utility of NGS to track respiratory viral infection outbreaks and delineate between community acquired and nosocomial infections in our cancer units. Retrospective chart review conducted at a single site. All patients diagnosed with multiple myeloma who developed symptoms suggestive of upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) along with a respiratory viral panel (RVP) test positive for HPIV 3 between April 1, 2016, to June 30, 2016, were included. Sequencing was performed on the Illumina MiSeq™. To gain understanding regarding community strains of HPIV 3 during the same season, we also performed NGS on HPIV3 strains isolated from pediatric cases. We saw a cluster of 13 cases of HPIV3 infections in the myeloma unit. Using standard epidemiologic criteria, 3 cases were considered community acquired, 7 cases developed infection during treatment in the cancer infusion center, wh...Continue Reading

Citations

Jun 15, 2018·Expert Review of Molecular Diagnostics·Alexander L Greninger
Sep 21, 2018·Journal of Clinical Microbiology·Kristine M WylieGregory A Storch
Dec 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amanda M CastoAlexander L Greninger
Jan 1, 2018·Current Treatment Options in Infectious Diseases·Pablo E Bonvehí, Elena R Temporiti
Jan 9, 2019·Frontiers in Microbiology·Diego R HijanoRandall T Hayden

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