PMID: 9524188May 9, 1998Paper

The role of NF-kappaB in retinal neovascularization in the rat. Possible involvement of cytokine-induced neutrophil chemoattractant (CINC), a member of the interleukin-8 family

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
A YoshidaH Inomata

Abstract

Hypoxia precedes neovascularization in many retinal diseases that can lead to irreversible vision loss. The transcription factor NF-kappaB is activated by hypoxia and regulates the expression of many genes, including angiogenic factors. The relation between the NF-kappaB activation and the cytokine-induced neutrophil chemoattractant (CINC), a member of the interleukin-8 (IL-8) family, was investigated by immunohistochemistry in a rat model of proliferative retinopathy presumably caused by relative hypoxia. Activated NF-kappaB and CINC immunoreactivity was detected in retinal glial cells in the nonperfused retina and in neovascular cells. Activated NF-kappaB was detected before the CINC staining, and both of these events occurred before the development of neovascularization. The intensity of both activated NF-kappaB and CINC staining remained increased during the development of neovascularization and then declined as neovascularization regressed. In rat retinal glial cells in vitro, dexamethasone, an inhibitor of NF-kappaB activation, prevented the hypoxia-induced increase in the amount of CINC mRNA. Furthermore, CINC induced neovascularization in a rat corneal pocket model. These results suggest that hypoxia-induced activation ...Continue Reading

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Citations

May 6, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Andreas Bringmann, Peter Wiedemann
Aug 28, 2001·Journal of Diabetes and Its Complications·T YuukiS Kishi
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Apr 17, 2010·Molecules and Cells·Agnieszka LobodaJozef Dulak
Feb 6, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shigeo YoshidaToshihiro Kono
Dec 17, 2015·Omics : a Journal of Integrative Biology·Akanksha Gupta, Sonika Bhatnagar
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Dec 27, 2005·Progress in Retinal and Eye Research·Chikako HaradaTakayuki Harada

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