PMID: 8610127Apr 2, 1996Paper

The role of NF-kappaB in the angiogenic response of coronary microvessel endothelial cells

Proceedings of the National Academy of Sciences of the United States of America
R A StoltzMichal Laniado-Schwartzman

Abstract

The activation of nuclear factor (NF)-kappaB by 12(R)-hydroxyeicosatrienoic acid [12(R)-HETrE], an arachidonic acid metabolite with potent stereospecific proinflammatory and angiogenic properties, was examined and its role in the angiogenic response was determined in capillary endothelial cells derived from coronary microvessels. Electrophoretic mobility-shift assay of nuclear protein extracts from cells treated with 12(R)-HETrE demonstrated a rapid and stereospecific time- and concentration-dependent increase in the binding activity of NF-kappaB, which was inhibitable by the antioxidants N-acetylcysteine, butylated hydroxyanisole, and pyrrolidine dithiocarbamate and was partially attenuated by the protein kinase C inhibitors, staurosporine and calphostin C. Neither 12(S)-HETrE nor other related eicosanoids--e.g., 12(R)-HETE, 12(S)-HETE, and leukotriene B4--stimulated the activation of NF-kappaB relative to 12(R)-HETrE, substantiating the claim for a specific receptor-mediated mechanism. 12(R)-HETrE stimulated the formation of capillary-like cords of microvessel endothelial cells distinguishable from a control; this effect was comparable to that observed with basic fibroblast growth factor (bFGF). Inhibition of NF-kappaB activa...Continue Reading

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Citations

Oct 11, 2002·Free Radical Biology & Medicine·Nilanjana Maulik, Dipak K Das
May 7, 2003·Trends in Cardiovascular Medicine·Yeshao WenJerry Nadler
Jan 1, 1998·Trends in Cardiovascular Medicine·J F Schmedtje, Y S Ji
Oct 2, 2003·Prostaglandins & Other Lipid Mediators·Mustapha KandouzKenneth V Honn
Mar 7, 2001·Antioxidants & Redox Signaling·N L ParinandiV Natarajan
Jan 1, 1999·Journal of Clinical Gastroenterology·Z Morise, M B Grisham
Sep 24, 2009·The Journal of Pharmacology and Experimental Therapeutics·Lars BellnerMichal Laniado Schwartzman
Jun 20, 1998·The Journal of Cell Biology·M ScatenaC M Giachelli
Oct 26, 2007·Journal of Cellular Physiology·M S KiranP R Sudhakaran
Jul 8, 2015·Journal of Cancer Prevention·Young Sun Hwang, Paul F Lindholm
May 9, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A YoshidaH Inomata
Jul 13, 2005·The Journal of Pharmacology and Experimental Therapeutics·Alexandre MezentsevMichal Laniado-Schwartzman
Jan 24, 2002·The Journal of Pharmacology and Experimental Therapeutics·Iolanda M FierroCharles N Serhan
Mar 20, 2002·The Journal of Biological Chemistry·Alexander MezentsevMichal Laniado-Schwartzman
Apr 17, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·B VailhéJ J Feige
Nov 2, 2018·Biological & Pharmaceutical Bulletin·Orawin PrangsaengtongKeiichi Koizumi
Jan 20, 2021·Molecular Neurobiology·Arianna Manini, Leonardo Pantoni
Dec 27, 2005·Progress in Retinal and Eye Research·Chikako HaradaTakayuki Harada

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