The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight

International Journal of Molecular Sciences
Brooke ArmisteadHamid-Reza Kohan-Ghadr

Abstract

The NFκB protein family regulates numerous pathways within the cell-including inflammation, hypoxia, angiogenesis and oxidative stress-all of which are implicated in placental development. The placenta is a critical organ that develops during pregnancy that primarily functions to supply and transport the nutrients required for fetal growth and development. Abnormal placental development can be observed in numerous disorders during pregnancy, including fetal growth restriction, miscarriage, and preeclampsia (PE). NFκB is highly expressed in the placentas of women with PE, however its contributions to the syndrome are not fully understood. In this review we discuss the molecular actions and related pathways of NFκB in the placenta and highlight areas of research that need attention.

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Citations

May 18, 2020·Endocrinology·Brooke ArmisteadHamid-Reza Kohan-Ghadr
Aug 8, 2020·International Journal of Molecular Sciences·Agata SakowiczLidia Biesiada
Aug 21, 2020·Scientific Reports·Soo-Young OhCheong-Rae Roh
Jan 6, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Bambanani ZozoThajasvarie Naicker
Nov 22, 2020·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Dec 31, 2020·Human Reproduction Update·Arthur ColsonAmanda N Sferruzzi-Perri
Jan 16, 2021·International Journal of Molecular Sciences·Maciej W SochaMichał Wiciński
Jun 12, 2021·Der Pathologe·T MenterE Bruder
Nov 4, 2021·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Charu SharmaPraveen Sharma

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Methods Mentioned

BETA
ubiquitination
immunoprecipitation
nuclear translocation

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