The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model.

Autism Research : Official Journal of the International Society for Autism Research
Hafiz M MahmoodShakir D AlSharari

Abstract

Nicotinic receptors are distributed throughout the central and peripheral nervous system. Postmortem studies have reported that some nicotinic receptor subtypes are altered in the brains of autistic people. Recent studies have demonstrated the importance of nicotinic acetylcholine receptors (nAChRs) in the autistic behavior of BTBR T + tf/J mouse model of autism. This study was undertaken to examine the behavioral effects of targeted nAChRs using pharmacological ligands, including nicotine and mecamylamine in BTBR T + tf/J and C57BL/6J mice in a panel of behavioral tests relating to autism. These behavioral tests included the three-chamber social interaction, self-grooming, marble burying, locomotor activity, and rotarod test. We examined the effect of various oral doses of nicotine (50, 100, and 400 mcg/mL; po) over a period of 2 weeks in BTBR T + tf/J mouse model. The results indicated that the chronic administration of nicotine modulated sociability and repetitive behavior in BTBR T + tf/J mice while no effects observed in C57BL/6J mice. Furthermore, the nonselective nAChR antagonist, mecamylamine, reversed nicotine effects on sociability and increased repetitive behaviors in BTBR T + tf/J mice. Overall, the findings indicat...Continue Reading

References

Jan 1, 1977·Pharmacology, Biochemistry, and Behavior·P C Hatchell, A C Collins
Jun 1, 1990·Trends in Pharmacological Sciences·S Wonnacott
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·M J MarksA C Collins
Feb 1, 1989·Journal of Neuroscience Research·P De Sarno, E Giacobini
Jan 1, 1988·Life Sciences·K ElrodW J Jackson
May 1, 1988·Pharmacology, Biochemistry, and Behavior·A C CollinsM J Marks
Apr 1, 1996·Psychopharmacology·S F RobinsonA C Collins
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R FreedmanW Byerley
Feb 1, 1997·Trends in Neurosciences·S Wonnacott
Sep 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M NisellT H Svensson
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·L KanýtS Pöğün
Jan 12, 2000·Brain Research·R IsolaM Hadjiconstantinou
Mar 27, 2001·British Journal of Pharmacology·S CheetaS E File
Jun 30, 2001·The American Journal of Psychiatry·E K PerryG L Wenk
Sep 15, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·A A SilverP R Sanberg
Oct 30, 2001·The Journal of Clinical Psychiatry·A A SilverP R Sanberg
Jun 22, 2002·Brain : a Journal of Neurology·M LeeE Perry
Sep 25, 2002·Neuroscience Letters·Helena GäddnäsLiisa Ahtee
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·Martha M FaradayNeil E Grunberg
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Evelyn K LambeGeorge K Aghajanian
Mar 5, 2003·Journal of Neurochemistry·Darlene H BrunzellMarina R Picciotto
Jun 5, 2003·Reviews of Physiology, Biochemistry and Pharmacology·R C HoggD Bertrand
Sep 13, 2003·The Journal of Pharmacology and Experimental Therapeutics·M I DamajB R Martin
Mar 1, 1957·Journal of the American Pharmaceutical Association·N W DUNHAM, T S MIYA
Mar 30, 2004·Brain Research. Molecular Brain Research·C M Martin-RuizE K Perry
Apr 28, 2004·Psychopharmacology·Simon N KatnerMichael A Taffe
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Laura Cousino KleinHelen M Kamens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.